Halil I Yakut1, Tuba Kurt2, Nermin Uncu2, F Semsa Cayci3, Banu Celikel Acar4. 1. Department of Pediatrics, University of Health Sciences, Ankara City Hospital, Ankara, Turkey. 2. Department of Pediatric Rheumatology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey. 3. Department of Pediatric Nephrology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey. 4. Department of Pediatric Rheumatology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey. banuacar@gmail.com.
Abstract
BACKGROUND: Henoch-Schönlein purpura (HSP) is a systemic small-vessel vasculitis that occurs mainly in children. The aim was to evaluate the blood neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume (MPV) in patients with HSP and to investigate the relationship with gastrointestinal and renal involvement. METHODS: Children with HSP and healthy individuals as controls were included. Hemoglobin level, white blood cell count, platelet count, NLR, MPV erythrocyte sedimentation rate and C-reactive protein were evaluated. RESULTS: There were 71 HSP children and 74 controls. NLR was significantly higher in HSP patients with gastrointestinal bleeding than without gastrointestinal bleeding (p < 0,001). The optimal cutoff value of NLR for predicting gastrointestinal bleeding was 2.05, with 93 % sensitivity and 62 % specificity. MPV was significantly higher in HSP patients with renal involvement than without renal involvement (p = 0,027). CONCLUSIONS: Blood NLR and MPV may be useful markers to identify gastrointestinal and renal involvement in HSP patients. Sociedad Argentina de Pediatría.
BACKGROUND: Henoch-Schönlein purpura (HSP) is a systemic small-vessel vasculitis that occurs mainly in children. The aim was to evaluate the blood neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume (MPV) in patients with HSP and to investigate the relationship with gastrointestinal and renal involvement. METHODS:Children with HSP and healthy individuals as controls were included. Hemoglobin level, white blood cell count, platelet count, NLR, MPV erythrocyte sedimentation rate and C-reactive protein were evaluated. RESULTS: There were 71 HSPchildren and 74 controls. NLR was significantly higher in HSPpatients with gastrointestinal bleeding than without gastrointestinal bleeding (p < 0,001). The optimal cutoff value of NLR for predicting gastrointestinal bleeding was 2.05, with 93 % sensitivity and 62 % specificity. MPV was significantly higher in HSPpatients with renal involvement than without renal involvement (p = 0,027). CONCLUSIONS: Blood NLR and MPV may be useful markers to identify gastrointestinal and renal involvement in HSPpatients. Sociedad Argentina de Pediatría.