Nora Arias-Bujanda1, Alba Regueira-Iglesias1, Triana Blanco-Pintos1, Manuela Alonso-Sampedro2, Marta Relvas3, Maria Mercedes González-Peteiro1, Carlos Balsa-Castro1, Inmaculada Tomás1. 1. Oral Sciences Research Group, Special Needs Unit, Department of Surgery and Medical-surgical Specialties, School of Medicine and Dentistry, Health Research Institute Foundation of Santiago (FIDIS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain. 2. Department of Internal Medicine and Clinical Epidemiology, Complejo Hospitalario Universitario, Santiago de Compostela, Spain. 3. Instituto Universitário de Ciências da Saúde-Norte, Centro de Investigação de Ciências da Saúde, Gandra, Portugal.
Abstract
AIM: To obtain salivary interleukin (IL) 1β-based models to predict the probability of the occurrence of periodontitis, differentiating by smoking habit. MATERIALS/ METHODS: A total of 141 participants were recruited, 62 periodontally healthy controls and 79 subjects affected by periodontitis. Fifty of the diseased patients were given non-surgical periodontal treatment and showed significant clinical improvement in 2 months. IL1β was measured in the salivary samples using the Luminex instrument. Binary logistic regression models were obtained to differentiate untreated periodontitis from periodontal health (first modelling) and untreated periodontitis from treated periodontitis (second modelling), distinguishing between non-smokers and smokers. The area under the curve (AUC) and classification measures were calculated. RESULTS: In the first modelling, IL1β presented AUC values of 0.830 for non-smokers and 0.689 for smokers (accuracy = 77.6% and 70.7%, respectively). In the second, the predictive models revealed AUC values of 0.671 for non-smokers and 0.708 for smokers (accuracy = 70.0% and 75.0%, respectively). CONCLUSION: Salivary IL1β has an excellent diagnostic capability when it comes to distinguishing systemically healthy patients with untreated periodontitis from those who are periodontally healthy, although this discriminatory potential is reduced in smokers. The diagnostic capacity of salivary IL1β remains acceptable for differentiating between untreated and treated periodontitis.
AIM: To obtain salivary interleukin (IL) 1β-based models to predict the probability of the occurrence of periodontitis, differentiating by smoking habit. MATERIALS/ METHODS: A total of 141 participants were recruited, 62 periodontally healthy controls and 79 subjects affected by periodontitis. Fifty of the diseased patients were given non-surgical periodontal treatment and showed significant clinical improvement in 2 months. IL1β was measured in the salivary samples using the Luminex instrument. Binary logistic regression models were obtained to differentiate untreated periodontitis from periodontal health (first modelling) and untreated periodontitis from treated periodontitis (second modelling), distinguishing between non-smokers and smokers. The area under the curve (AUC) and classification measures were calculated. RESULTS: In the first modelling, IL1β presented AUC values of 0.830 for non-smokers and 0.689 for smokers (accuracy = 77.6% and 70.7%, respectively). In the second, the predictive models revealed AUC values of 0.671 for non-smokers and 0.708 for smokers (accuracy = 70.0% and 75.0%, respectively). CONCLUSION: Salivary IL1β has an excellent diagnostic capability when it comes to distinguishing systemically healthy patients with untreated periodontitis from those who are periodontally healthy, although this discriminatory potential is reduced in smokers. The diagnostic capacity of salivary IL1β remains acceptable for differentiating between untreated and treated periodontitis.