Poonam Singh1, Vaishali Chaudhari2. 1. Department of Pediatrics, Surat Municipal Institute of Medical Education and Research, Surat, India. 2. Department of Pediatrics, Surat Municipal Institute of Medical Education and Research, Surat, India. Correspondence to: Dr Vaishali Chaudhari, Department of Pediatrics, Surat Municipal Institute of Medical Education and Research, Surat, India. chaudharivaishali400@gmail.com.
Abstract
OBJECTIVE: To determine if vitamin D status is affected in term neonates with early onset sepsis and its association with outcome. METHODS: Study was done at a level 3 neonatal unit on 140 neonates. Term neonates with early onset sepsis (study group, 70 patients) and without sepsis (control group, 70 patients) were enrolled. RESULTS: Mean neonatal vitamin D level in the study group was 16.00 (10.49) ng/mL and in the control group, was 29.07(8.36) ng/mL (P =0.061). In the study group 80% (n=56) babies had low vitamin D levels (<32 ng/mL) among whom 51.7% (n=29) had severe vitamin D deficiency (<11ng/mL). In the control group, 58.5% (n=41) had low vitamin D levels of whom, 9.8% (n=4) had severe vitamin D deficiency (P<0.001 and P<0.001, respectively). Mortality and highly probable sepsis were more common with vitamin D levels <11ng/mL in the study group (P= 0.005 and P=0.006, respectively). CONCLUSIONS: Vitamin D is deficient in neonates with early onset sepsis and is associated with increased sepsis severity and mortality.
OBJECTIVE: To determine if vitamin D status is affected in term neonates with early onset sepsis and its association with outcome. METHODS: Study was done at a level 3 neonatal unit on 140 neonates. Term neonates with early onset sepsis (study group, 70 patients) and without sepsis (control group, 70 patients) were enrolled. RESULTS: Mean neonatal vitamin D level in the study group was 16.00 (10.49) ng/mL and in the control group, was 29.07(8.36) ng/mL (P =0.061). In the study group 80% (n=56) babies had low vitamin D levels (<32 ng/mL) among whom 51.7% (n=29) had severe vitamin D deficiency (<11ng/mL). In the control group, 58.5% (n=41) had low vitamin D levels of whom, 9.8% (n=4) had severe vitamin D deficiency (P<0.001 and P<0.001, respectively). Mortality and highly probable sepsis were more common with vitamin D levels <11ng/mL in the study group (P= 0.005 and P=0.006, respectively). CONCLUSIONS:Vitamin D is deficient in neonates with early onset sepsis and is associated with increased sepsis severity and mortality.