Lucie Demaria1, Raphael Borie2, Khadija Benali3, Eve Piekarski3, Julia Goossens1, Elisabeth Palazzo1, Marine Forien1, Philippe Dieudé1, Bruno Crestani2, Sébastien Ottaviani4. 1. AP-HP, Hôpital Bichat-Claude Bernard, Service de Rhumatologie, 46 rue Henri Huchard, 75018, Paris, France. 2. AP-HP, Hôpital Bichat-Claude Bernard, Service de Pneumologie, Paris, France. 3. AP-HP, Hôpital Bichat-Claude Bernard, Service de Médecine Nucléaire, Paris, France. 4. AP-HP, Hôpital Bichat-Claude Bernard, Service de Rhumatologie, 46 rue Henri Huchard, 75018, Paris, France. sebastien.ottaviani@aphp.fr.
Abstract
OBJECTIVE: Bone sarcoidosis is usually rare. Imaging procedures such as fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) can reveal bone sarcoidosis with better sensitivity than conventional radiography. We aimed to describe bone sarcoidosis involvement detected with 18F-FDG PET/CT. METHODS: This was an observational retrospective study of individuals with pulmonary sarcoidosis who underwent 18F-FDG PET/CT. According to the ATS/ERS/WASOG criteria, sarcoidosis was diagnosed by the presence of clinical and/or imaging features of sarcoidosis and evidence of non-caseating epithelioid granulomas on a biopsy. We assessed clinical and 18F-FDG PET/CT characteristics. RESULTS: Data for 85 patients with sarcoidosis (56.5% female, median age 47 [range 21-80] years) were analyzed. The median follow-up was 4 years. Among 56 patients, sarcoidosis occurred in more than three organs. According to ATS/ERS/WASOG criteria, bone sarcoidosis was diagnosed in 12 (14%) patients. The spine was the most commonly affected location (92%, n = 11), followed by the pelvis (67%, n = 8), sternum (33%, n = 4), humerus (25%, n = 3), and fingers (17%, n = 2). Only peripheral adenopathy was associated with bone sarcoidosis (p = 0.04). Seven patients had a 18F-FDG PET/CT follow-up, all showing a decrease of bone lesions. CONCLUSION: Bone sarcoidosis occurred in 14% of patients with sarcoidosis, affecting multiple bones and mostly the axial skeleton. 18F-FDG PET/CT seems a sensitive tool for diagnosis and follow-up of bone sarcoidosis.
OBJECTIVE:Bone sarcoidosis is usually rare. Imaging procedures such as fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) can reveal bone sarcoidosis with better sensitivity than conventional radiography. We aimed to describe bone sarcoidosis involvement detected with 18F-FDG PET/CT. METHODS: This was an observational retrospective study of individuals with pulmonary sarcoidosis who underwent 18F-FDG PET/CT. According to the ATS/ERS/WASOG criteria, sarcoidosis was diagnosed by the presence of clinical and/or imaging features of sarcoidosis and evidence of non-caseating epithelioid granulomas on a biopsy. We assessed clinical and 18F-FDG PET/CT characteristics. RESULTS: Data for 85 patients with sarcoidosis (56.5% female, median age 47 [range 21-80] years) were analyzed. The median follow-up was 4 years. Among 56 patients, sarcoidosis occurred in more than three organs. According to ATS/ERS/WASOG criteria, bone sarcoidosis was diagnosed in 12 (14%) patients. The spine was the most commonly affected location (92%, n = 11), followed by the pelvis (67%, n = 8), sternum (33%, n = 4), humerus (25%, n = 3), and fingers (17%, n = 2). Only peripheral adenopathy was associated with bone sarcoidosis (p = 0.04). Seven patients had a 18F-FDG PET/CT follow-up, all showing a decrease of bone lesions. CONCLUSION:Bone sarcoidosis occurred in 14% of patients with sarcoidosis, affecting multiple bones and mostly the axial skeleton. 18F-FDG PET/CT seems a sensitive tool for diagnosis and follow-up of bone sarcoidosis.
Authors: Rémy L Mostard; Léonne Prompers; Rene E Weijers; Marinus J van Kroonenburgh; Petal A Wijnen; Piet P Geusens; Marjolein Drent Journal: Clin Nucl Med Date: 2012-01 Impact factor: 7.794
Authors: Jeffrey A Sparks; Jakob I McSparron; Nehal Shah; Piran Aliabadi; Vera Paulson; Christopher H Fanta; Jonathan S Coblyn Journal: Semin Arthritis Rheum Date: 2014-07-15 Impact factor: 5.532