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Literature DB >> 32198186

Putting the brakes on a myosin motor.

Abstract

Insulin-stimulated trafficking of GLUT4 requires the myosin motor Myo1C and signaling adaptor 14-3-3β. Originally, it was thought that 14-3-3β promotes GLUT4 transport by binding the Myo1C lever arm and activating the Myo1C motor. New work by Ji and Ostap using in vitro assays reveals that 14-3-3β binding actually inhibits Myo1C motility, prompting reconsideration of the functional relationship between 14-3-3β and Myo1C and the regulatory potential of atypical light chains.

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Year: 2020 PMID： 32198186 PMCID： PMC7086042 DOI： 10.1074/jbc.H120.013153

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

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References

11 in total

1. Unconventional myosin Myo1c promotes membrane fusion in a regulated exocytic pathway.

Authors: Avirup Bose; Stacey Robida; Paul S Furcinitti; Anil Chawla; Kevin Fogarty; Silvia Corvera; Michael P Czech
Journal: Mol Cell Biol Date: 2004-06 Impact factor: 4.272

Review 2. GLUT4 exocytosis.

Authors: Jacqueline Stöckli; Daniel J Fazakerley; David E James
Journal: J Cell Sci Date: 2011-12-15 Impact factor: 5.285

3. CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes.

Authors: Ming Fai Yip; Georg Ramm; Mark Larance; Kyle L Hoehn; Mark C Wagner; Michael Guilhaus; David E James
Journal: Cell Metab Date: 2008-11 Impact factor: 27.287

4. Crystal structure of human myosin 1c--the motor in GLUT4 exocytosis: implications for Ca2+ regulation and 14-3-3 binding.

Authors: Stefan Münnich; Manuel H Taft; Dietmar J Manstein
Journal: J Mol Biol Date: 2014-03-14 Impact factor: 5.469

5. The regulatory protein 14-3-3β binds to the IQ motifs of myosin-IC independent of phosphorylation.

Authors: Huan-Hong Ji; E Michael Ostap
Journal: J Biol Chem Date: 2019-12-06 Impact factor: 5.157

6. Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c.

Authors: Xiao-Wei Chen; Dara Leto; Shian-Huey Chiang; Qian Wang; Alan R Saltiel
Journal: Dev Cell Date: 2007-09 Impact factor: 12.270

Putting the brakes on a myosin motor.

1. Unconventional myosin Myo1c promotes membrane fusion in a regulated exocytic pathway.

Review 2. GLUT4 exocytosis.

3. CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes.

4. Crystal structure of human myosin 1c--the motor in GLUT4 exocytosis: implications for Ca2+ regulation and 14-3-3 binding.

5. The regulatory protein 14-3-3β binds to the IQ motifs of myosin-IC independent of phosphorylation.

6. Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c.

7. CIB1 and CaBP1 bind to the myo1c regulatory domain.

8. Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c.

Review 9. Myosin light chains: Teaching old dogs new tricks.

10. Myo1c binding to submembrane actin mediates insulin-induced tethering of GLUT4 vesicles.