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Literature DB >> 32197477

Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process.

Che C Colpitts¹, Pei-Ling Tsai¹, Mirjam B Zeisel².

Abstract

Hepatitis C virus (HCV) is a major cause of chronic hepatitis and liver disease worldwide. Its tissue and species tropism are largely defined by the viral entry process that is required for subsequent productive viral infection and establishment of chronic infection. This review provides an overview of the viral and host factors involved in HCV entry into hepatocytes, summarizes our understanding of the molecular mechanisms governing this process and highlights the therapeutic potential of host-targeting entry inhibitors.

Entities: CellLine Chemical Disease Gene Species

Keywords: cell-to-cell transmission; endocytosis; fusion; hepatitis C virus; hepatocyte; viral entry

Year: 2020 PMID： 32197477 DOI： 10.3390/ijms21062091

Source DB: PubMed Journal: Int J Mol Sci ISSN： 1422-0067 Impact factor: 5.923

11 in total

Review 1. Impact of direct-acting antiviral regimens on hepatic and extrahepatic manifestations of hepatitis C virus infection.

Authors: Iman Ibrahim Salama; Hala M Raslan; Ghada A Abdel-Latif; Somaia I Salama; Samia M Sami; Fatma A Shaaban; Aida M Abdelmohsen; Walaa A Fouad
Journal: World J Hepatol Date: 2022-06-27

2. Design of a native-like secreted form of the hepatitis C virus E1E2 heterodimer.

Authors: Johnathan D Guest; Ruixue Wang; Khadija H Elkholy; Andrezza Chagas; Kinlin L Chao; Thomas E Cleveland; Young Chang Kim; Zhen-Yong Keck; Alexander Marin; Abdul S Yunus; Roy A Mariuzza; Alexander K Andrianov; Eric A Toth; Steven K H Foung; Brian G Pierce; Thomas R Fuerst
Journal: Proc Natl Acad Sci U S A Date: 2021-01-19 Impact factor: 12.779

Review 3. Hepatitis C Virus and Hepatocellular Carcinoma: When the Host Loses Its Grip.

Authors: Kaku Goto; Armando Andres Roca Suarez; Florian Wrensch; Thomas F Baumert; Joachim Lupberger
Journal: Int J Mol Sci Date: 2020-04-26 Impact factor: 5.923

4. Ribosome Pausing at Inefficient Codons at the End of the Replicase Coding Region Is Important for Hepatitis C Virus Genome Replication.

Authors: Gesche K Gerresheim; Carolin S Hess; Lyudmila A Shalamova; Markus Fricke; Manja Marz; Dmitri E Andreev; Ivan N Shatsky; Michael Niepmann
Journal: Int J Mol Sci Date: 2020-09-22 Impact factor: 5.923

5. Induction of broadly neutralizing antibodies using a secreted form of the hepatitis C virus E1E2 heterodimer as a vaccine candidate.

Authors: Ruixue Wang; Saori Suzuki; Johnathan D Guest; Brigitte Heller; Maricar Almeda; Alexander K Andrianov; Alexander Marin; Roy A Mariuzza; Zhen-Yong Keck; Steven K H Foung; Abdul S Yunus; Brian G Pierce; Eric A Toth; Alexander Ploss; Thomas R Fuerst
Journal: Proc Natl Acad Sci U S A Date: 2022-03-09 Impact factor: 12.779

Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process.

Review 1. Impact of direct-acting antiviral regimens on hepatic and extrahepatic manifestations of hepatitis C virus infection.

2. Design of a native-like secreted form of the hepatitis C virus E1E2 heterodimer.

Review 3. Hepatitis C Virus and Hepatocellular Carcinoma: When the Host Loses Its Grip.

4. Ribosome Pausing at Inefficient Codons at the End of the Replicase Coding Region Is Important for Hepatitis C Virus Genome Replication.

5. Induction of broadly neutralizing antibodies using a secreted form of the hepatitis C virus E1E2 heterodimer as a vaccine candidate.

Review 6. Viral Hepatitis, Cholesterol Metabolism, and Cholesterol-Lowering Natural Compounds.

Review 7. Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies.

8. Safety and Efficacy of Avaren-Fc Lectibody Targeting HCV High-Mannose Glycans in a Human Liver Chimeric Mouse Model.

Review 9. Hepatitis C Viral Replication Complex.

Review 10. Inhibition of Viral Membrane Fusion by Peptides and Approaches to Peptide Design.