| Literature DB >> 32196941 |
Sajad Yaghoubi1, Hamid Najminejad2, Mehran Dabaghian3, Mohammad Hossein Karimi4, Meghdad Abdollahpour-Alitappeh5, Fariba Rad6,7, Motahareh Mahi-Birjand8, Shiva Mohammadi9, Fatemeh Mohseni10, Mohammad Sobhani Lari5, Gholam Hossein Teymouri11, Esmat Rigi Yousofabadi12, Abbas Salmani10, Nader Bagheri13.
Abstract
Exosomes, as natural occurring vesicles, play highly important roles in the behavior and fate of ischemic diseases and different tumors. Secretion, composition, and function of exosomes are remarkably influenced by hypoxia in ischemic diseases and tumor microenvironment. Exosomes secreted from hypoxic cells affect development, growth, angiogenesis, and progression in ischemic diseases and tumors through a variety of signaling pathways. In this review article, we discuss how hypoxia affects the quantity and quality of exosomes, and review the mechanisms by which hypoxic cell-derived exosomes regulate ischemic cell behaviors in both cancerous and noncancerous cells.Entities:
Keywords: HIF-α; exosomes; hypoxia; ischemic diseases; metastasis; microvesicles; tumor microenvironment
Year: 2020 PMID： 32196941 DOI： 10.1002/iub.2275
Source DB: PubMed Journal: IUBMB Life ISSN： 1521-6543 Impact factor: 3.885