Gabriel Adrian1, Maria Gebre-Medhin2, Elisabeth Kjellén2, Elinore Wieslander2, Björn Zackrisson3, Per Nilsson2,4. 1. Department of Clinical Sciences Lund, Oncology, Skåne University Hospital, Lund University, Lund, Sweden. 2. Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Lund University, Lund, Sweden. 3. Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden. 4. Department of Clinical Sciences, Medical Radiation Physics, Skåne University Hospital, Lund University, Lund, Sweden.
Abstract
BACKGROUND: A large tumor volume negatively impacts the outcome of radiation therapy (RT). Altered fractionation (AF) can improve local control (LC) compared with conventional fractionation (CF). The aim of the present study was to investigate if response to AF differs with tumor volume in oropharyngeal cancer. METHODS: Three hundred and twenty four patients with oropharyngeal cancer treated in a randomized, phase III trial comparing CF (2 Gy/d, 5 d/wk, 7 weeks, total dose 68 Gy) to AF (1.1 Gy + 2 Gy/d, 5 d/wk, 4.5 weeks, total dose 68 Gy) were analyzed. RESULTS: Tumor volume had less impact on LC for patients treated with AF. There was an interaction between tumor volume and fractionation schedule (P = .039). This differential response was in favor of CF for small tumors and of AF for large tumors. CONCLUSION: AF diminishes the importance of tumor volume for local tumor control in oropharyngeal cancer.
BACKGROUND: A large tumor volume negatively impacts the outcome of radiation therapy (RT). Altered fractionation (AF) can improve local control (LC) compared with conventional fractionation (CF). The aim of the present study was to investigate if response to AF differs with tumor volume in oropharyngeal cancer. METHODS: Three hundred and twenty four patients with oropharyngeal cancer treated in a randomized, phase III trial comparing CF (2 Gy/d, 5 d/wk, 7 weeks, total dose 68 Gy) to AF (1.1 Gy + 2 Gy/d, 5 d/wk, 4.5 weeks, total dose 68 Gy) were analyzed. RESULTS: Tumor volume had less impact on LC for patients treated with AF. There was an interaction between tumor volume and fractionation schedule (P = .039). This differential response was in favor of CF for small tumors and of AF for large tumors. CONCLUSION: AF diminishes the importance of tumor volume for local tumor control in oropharyngeal cancer.
Authors: Gabriel Adrian; Henrik Carlsson; Elisabeth Kjellén; Johanna Sjövall; Björn Zackrisson; Per Nilsson; Maria Gebre-Medhin Journal: Radiat Oncol Date: 2022-06-14 Impact factor: 4.309
Authors: Elena Russo; Andrea Costantino; Giuseppe Mercante; Giuseppe Spriano; Armando De Virgilio Journal: Cancers (Basel) Date: 2022-09-02 Impact factor: 6.575