Matthew R Allen1,2,3,4, Elizabeth A Swallow5, Corinne E Metzger5. 1. Department of Anatomy and Cell Biology, MS 5035, Indiana University School of Medicine, 635 Barnhill Dr, Indianapolis, IN, 46202, USA. matallen@iu.edu. 2. Department of Medicine - Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, USA. matallen@iu.edu. 3. Department of Biomedical Engineering, Indiana University Purdue University of Indianapolis, Indianapolis, IN, USA. matallen@iu.edu. 4. Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA. matallen@iu.edu. 5. Department of Anatomy and Cell Biology, MS 5035, Indiana University School of Medicine, 635 Barnhill Dr, Indianapolis, IN, 46202, USA.
Abstract
PURPOSE OF REVIEW: Kidney disease imparts profound skeletal changes, and unlike many other skeletal diseases, cortical bone is predominantly impacted. Significant advances in medical imaging have led to our ability to now obtain high-resolution three-dimensional views of cortical bone. This paper overviews recent work focused on cortical bone imaging, specifically cortical porosity, in kidney disease. RECENT FINDINGS: Although a number of clinical papers have used high-resolution imaging to assess cortical bone porosity, the most impactful work involves longitudinal study designs that have assessed cortical porosity changes over time. These latter studies demonstrate dramatic increases in cortical porosity in untreated individuals and a lack of clear efficacy in reversing porosity with treatment (although data are limited). Those papers providing longitudinal assessment, both clinical and pre-clinical, reveal powerful data about cortical porosity and provide a foundation upon which future studies can build.
PURPOSE OF REVIEW: Kidney disease imparts profound skeletal changes, and unlike many other skeletal diseases, cortical bone is predominantly impacted. Significant advances in medical imaging have led to our ability to now obtain high-resolution three-dimensional views of cortical bone. This paper overviews recent work focused on cortical bone imaging, specifically cortical porosity, in kidney disease. RECENT FINDINGS: Although a number of clinical papers have used high-resolution imaging to assess cortical bone porosity, the most impactful work involves longitudinal study designs that have assessed cortical porosity changes over time. These latter studies demonstrate dramatic increases in cortical porosity in untreated individuals and a lack of clear efficacy in reversing porosity with treatment (although data are limited). Those papers providing longitudinal assessment, both clinical and pre-clinical, reveal powerful data about cortical porosity and provide a foundation upon which future studies can build.
Authors: Sharon M Moe; Neal X Chen; Mark F Seifert; Rachel M Sinders; Dana Duan; Xianming Chen; Yun Liang; J Scott Radcliff; Kenneth E White; Vincent H Gattone Journal: Kidney Int Date: 2008-09-17 Impact factor: 10.612
Authors: Sharon M Moe; J Scott Radcliffe; Kenneth E White; Vincent H Gattone; Mark F Seifert; Xianming Chen; Blaire Aldridge; Neal X Chen Journal: J Bone Miner Res Date: 2011-11 Impact factor: 6.741
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Authors: Kyle K Nishiyama; Yves Pauchard; Lucas E Nikkel; Sapna Iyer; Chiyuan Zhang; Donald J McMahon; David Cohen; Steven K Boyd; Elizabeth Shane; Thomas L Nickolas Journal: J Bone Miner Res Date: 2015-03 Impact factor: 6.741
Authors: Daniel Cejka; Michael Weber; Danielle Diarra; Thomas Reiter; Franz Kainberger; Martin Haas Journal: Bone Date: 2014-04-05 Impact factor: 4.398