Literature DB >> 32193054

p62 as a therapeutic target for tumor.

Mengmin Tao1, Tian Liu1, Qidong You2, Zhengyu Jiang3.   

Abstract

p62/SQSTM1 (hereafter as p62) is a stress-inducible cellular protein, which interacts with various signaling proteins to regulate a variety of cellular functions. Growing lines of evidence supported a critical role of p62 in tumorigenesis, and p62 may become a therapeutic target for tumor. In this review, we summarize biological functions of structural domains of p62, reported bioactive molecules targeting p62, and the relationship between p62 and tumorigenesis.
Copyright © 2020 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Autophagy; NF-κB; Nrf2; Tumor; mTORC1; p62/SQSTM1

Year:  2020        PMID： 32193054     DOI： 10.1016/j.ejmech.2020.112231

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  8 in total

Review 1.  Regulated cell death (RCD) in cancer: key pathways and targeted therapies.

Authors:  Fu Peng; Minru Liao; Rui Qin; Shiou Zhu; Cheng Peng; Leilei Fu; Yi Chen; Bo Han
Journal:  Signal Transduct Target Ther       Date:  2022-08-13

2.  Changes of serum P62 and Beclin 1 in patients with pulmonary embolism during treatment and their predictive value for efficacy.

Authors:  Xuehui Zhang; Liu Huang; Lijiang Shao; Xuxia Chen; Jinguo Chu; Xueqin Chen
Journal:  Am J Transl Res       Date:  2022-09-15       Impact factor: 3.940

Review 3.  The Pathways Underlying the Multiple Roles of p62 in Inflammation and Cancer.

Authors:  Paulina Hennig; Gabriele Fenini; Michela Di Filippo; Tugay Karakaya; Hans-Dietmar Beer
Journal:  Biomedicines       Date:  2021-06-22

Review 4.  Recent Progress in Understanding the Action of Natural Compounds at Novel Therapeutic Drug Targets for the Treatment of Liver Cancer.

Authors:  Yannan Zheng; Wenhui Zhang; Lin Xu; Hua Zhou; Man Yuan; Hongxi Xu
Journal:  Front Oncol       Date:  2022-01-26       Impact factor: 6.244

5.  The regulation of autophagy by the miR-199a-5p/p62 axis was a potential mechanism of small cell lung cancer cisplatin resistance.

Authors:  Tiezhi Li; Helin Zhang; Zhichao Wang; Shaolin Gao; Xu Zhang; Haiyong Zhu; Na Wang; Honglin Li
Journal:  Cancer Cell Int       Date:  2022-03-15       Impact factor: 5.722

6.  Zhenzhu Xiaoji Decoction Induces Autophagy and Apoptosis Cell Death in Liver Cancer Cells through AKT/mTOR and JAK2/STAT3 Signaling Pathway.

Authors:  Yang Sun; Yue Sun; Songzhe Li; Xuelian Tao; Lingyun Cai
Journal:  Evid Based Complement Alternat Med       Date:  2022-04-06       Impact factor: 2.629

7.  miR-559 Inhibits Proliferation, Autophagy, and Angiogenesis of Hepatocellular Carcinoma Cells by Targeting PARD3.

Authors:  Chunjing Wang; Chengcheng Li; Rui Hao
Journal:  Mediators Inflamm       Date:  2022-09-05       Impact factor: 4.529

8.  p62 Overexpression Promotes Bone Metastasis of Lung Adenocarcinoma out of LC3-Dependent Autophagy.

Authors:  Dongqi Li; Chuanchun He; Fan Ye; En Ye; Hao He; Gong Chen; Jing Zhang
Journal:  Front Oncol       Date:  2021-05-21       Impact factor: 6.244
  8 in total

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