Literature DB >> 32190786

DDS promotes longevity through a microbiome-mediated starvation signal.

Haeri Choi1,2, Sung Chun Cho3, Young Wan Ha4, Billie Ocampo5, Shirley Park5, Shiwen Chen5, Christopher F Bennett5, Jeehae Han5, Ryan Rossner5, Jong-Sun Kang6,7, Yun-Ll Lee3, Sang Chul Park3,8, Matt Kaeberlein5.   

Abstract

The antibiotic diaminodiphenyl sulfone (DDS) is used in combination with other antibiotics as a first line treatment for leprosy. DDS has been previously reported to extend lifespan in Caenorhabditis elegans through inhibition of pyruvate kinase and decreased mitochondrial function. Here we report an alternative mechanism of action by which DDS promotes longevity in C. elegans by reducing folate production by the microbiome. This results in altered methionine cycle metabolite levels mimicking the effects of metformin and lifespan extension that is dependent on the starvation- and hypoxia-induced flavin containing monoxygenase, FMO-2.

Entities:  

Year:  2019        PMID： 32190786      PMCID： PMC7080190          DOI： 10.1016/j.tma.2019.07.001

Source DB:  PubMed          Journal:  Transl Med Aging        ISSN： 2468-5011


  45 in total

1.  Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity.

Authors:  Seung-Jae Lee; Ara B Hwang; Cynthia Kenyon
Journal:  Curr Biol       Date:  2010-11-18       Impact factor: 10.834

2.  Japan-Korea joint seminar: Asian aging core for longevity 2008 in Nagasaki - toward the establishment of an Asian aging research and education center - September 4th to 6th, 2008 at Huis ten Bosch, Nagasaki, Japan.

Authors:  Isao Shimokawa; Sang Chul Park; Nozomu Mori; Eun Seong Hwang
Journal:  Mech Ageing Dev       Date:  2008-11-25       Impact factor: 5.432

Review 3.  Treatment of leprosy.

Authors:  Hemanta Kumar Kar; Ruchi Gupta
Journal:  Clin Dermatol       Date:  2015 Jan-Feb       Impact factor: 3.541

Review 4.  Metformin--mode of action and clinical implications for diabetes and cancer.

Authors:  Ida Pernicova; Márta Korbonits
Journal:  Nat Rev Endocrinol       Date:  2014-01-07       Impact factor: 43.330

5.  Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls.

Authors:  C A Bannister; S E Holden; S Jenkins-Jones; C Ll Morgan; J P Halcox; G Schernthaner; J Mukherjee; C J Currie
Journal:  Diabetes Obes Metab       Date:  2014-07-31       Impact factor: 6.577

6.  Metformin improves healthspan and lifespan in mice.

Authors:  Alejandro Martin-Montalvo; Evi M Mercken; Sarah J Mitchell; Hector H Palacios; Patricia L Mote; Morten Scheibye-Knudsen; Ana P Gomes; Theresa M Ward; Robin K Minor; Marie-José Blouin; Matthias Schwab; Michael Pollak; Yongqing Zhang; Yinbing Yu; Kevin G Becker; Vilhelm A Bohr; Donald K Ingram; David A Sinclair; Norman S Wolf; Stephen R Spindler; Michel Bernier; Rafael de Cabo
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

7.  Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans.

Authors:  Christopher F Bennett; Jane J Kwon; Christine Chen; Joshua Russell; Kathlyn Acosta; Nikolay Burnaevskiy; Matthew M Crane; Alessandro Bitto; Helen Vander Wende; Marissa Simko; Victor Pineda; Ryan Rossner; Brian M Wasko; Haeri Choi; Shiwen Chen; Shirley Park; Gholamali Jafari; Bryan Sands; Carissa Perez Olsen; Alexander R Mendenhall; Philip G Morgan; Matt Kaeberlein
Journal:  PLoS Genet       Date:  2017-03-29       Impact factor: 5.917

8.  NHR-49/HNF4 integrates regulation of fatty acid metabolism with a protective transcriptional response to oxidative stress and fasting.

Authors:  Grace Y S Goh; Johnathan J Winter; Forum Bhanshali; Kelsie R S Doering; Regina Lai; Kayoung Lee; Elizabeth A Veal; Stefan Taubert
Journal:  Aging Cell       Date:  2018-03-05       Impact factor: 9.304

9.  Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans.

Authors:  Erica D Smith; Tammi L Kaeberlein; Brynn T Lydum; Jennifer Sager; K Linnea Welton; Brian K Kennedy; Matt Kaeberlein
Journal:  BMC Dev Biol       Date:  2008-05-05       Impact factor: 1.978

10.  Sorbitol treatment extends lifespan and induces the osmotic stress response in Caenorhabditis elegans.

Authors:  Devon Chandler-Brown; Haeri Choi; Shirley Park; Billie R Ocampo; Shiwen Chen; Anna Le; George L Sutphin; Lara S Shamieh; Erica D Smith; Matt Kaeberlein
Journal:  Front Genet       Date:  2015-10-27       Impact factor: 4.599
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  2 in total

1.  The listed, delisted, and sustainability of therapeutic medicines for dementia patients: the study is specific to South Korea.

Authors:  Jong Hoon Lee
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2022-02-05       Impact factor: 3.000

2.  Health and longevity studies in C. elegans: the "healthy worm database" reveals strengths, weaknesses and gaps of test compound-based studies.

Authors:  Nadine Saul; Steffen Möller; Francesca Cirulli; Alessandra Berry; Walter Luyten; Georg Fuellen
Journal:  Biogerontology       Date:  2021-03-08       Impact factor: 4.277
  2 in total

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