Literature DB >> 32188601

SUMOylation in development and neurodegeneration.

Tak-Yu Yau1, Oscar Molina1, Albert J Courey2.   

Abstract

In essentially all eukaryotes, proteins can be modified by the attachment of small ubiquitin-related modifier (SUMO) proteins to lysine side chains to produce branched proteins. This process of 'SUMOylation' plays essential roles in plant and animal development by altering protein function in spatially and temporally controlled ways. In this Primer, we explain the process of SUMOylation and summarize how SUMOylation regulates a number of signal transduction pathways. Next, we discuss multiple roles of SUMOylation in the epigenetic control of transcription. In addition, we evaluate the role of SUMOylation in the etiology of neurodegenerative disorders, focusing on Parkinson's disease and cerebral ischemia. Finally, we discuss the possibility that SUMOylation may stimulate survival and neurogenesis of neuronal stem cells.
© 2020. Published by The Company of Biologists Ltd.

Entities:  

Keywords:  Epigenetics; Neurodegenerative disorder; Post-translational protein modification; SUMO; Signal transduction; Ubiquitin-like protein

Mesh：

Year:  2020        PMID： 32188601      PMCID： PMC7097199          DOI： 10.1242/dev.175703

Source DB:  PubMed          Journal:  Development        ISSN： 0950-1991            Impact factor:   6.862


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