Domonkos Cseh1, Rachel E Climie2,3,4, Lucile Offredo2, Catherine Guibout2, Frédérique Thomas5, Luca Zanoli6, Nicolas Danchin2,5,7, James E Sharman4, Stéphane Laurent7, Xavier Jouven2, Pierre Boutouyrie2,7, Jean-Philippe Empana2. 1. From the Department of Physiology, Semmelweis University, Budapest, Hungary (D.C.). 2. Université de Paris, INSERM U970, Paris Cardiovascular Research Centre (PARCC), Integrative Epidemiology of Cardiovascular Disease team, Paris, France (R.E.C., L.O., C.G., N.D., X.J., P.B., J.-P.E.). 3. Baker Heart and Diabetes Institute, Melbourne, Australia (R.E.C.). 4. Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia (R.E.C., J.E.S.). 5. Investigations Préventives et Cliniques (IPC), Paris, France (F.T., N.D.). 6. University of Catania, Catania, Italy (L.Z.). 7. Department of Pharmacology, HEGP, APHP, Paris, France (N.D., S.L., P.B.).
Abstract
OBJECTIVE: Impaired baroreflex function is an early indicator of cardiovascular autonomic imbalance. Patients with type 2 diabetes mellitus (T2D) have decreased baroreflex sensitivity (BRS), however, whether the neural BRS (nBRS) and mechanical component of the BRS is altered in those with high metabolic risk (HMR, impaired fasting glucose and metabolic syndrome) or with overt T2D, is unknown. We examined this in a community-based observational study, the Paris Prospective Study III (PPS3). Approach and Results: In 7626 adults aged 50 to 75 years, resting nBRS (estimated by low-frequency gain, from carotid distension rate and RR [time elapsed between two successive R waves] intervals) and mechanical BRS were measured by high-precision carotid echotracking. The associations between overt T2D or HMR as compared with subjects with normal glucose metabolism and nBRS or mechanical BRS were quantified using multivariable linear regression analysis. There were 319 subjects with T2D (61±6 years, 77% male), 1450 subjects with HMR (60±6 years, 72% male), and 5857 subjects with normal glucose metabolism (59±6 years, 57% male). Compared with normal glucose metabolism, nBRS was significantly lower in HMR subjects (β=-0.07 [95% CI, -0.12 to -0.01]; P=0.029) and in subjects with T2D (β=-0.18 [95% CI, -0.29 to -0.07]; P=0.002) after adjustment for confounding and mediating factors. Subgroup analysis suggests significant and independent alteration in mechanical BRS only among HMR patients who had both impaired fasting glucose and metabolic syndrome. CONCLUSIONS: In this community-based study of individuals aged 50 to 75, a graded decrease in nBRS was observed in HMR subjects and patients with overt T2D as compared with normal glucose metabolism subjects.
OBJECTIVE: Impaired baroreflex function is an early indicator of cardiovascular autonomic imbalance. Patients with type 2 diabetes mellitus (T2D) have decreased baroreflex sensitivity (BRS), however, whether the neural BRS (nBRS) and mechanical component of the BRS is altered in those with high metabolic risk (HMR, impaired fasting glucose and metabolic syndrome) or with overt T2D, is unknown. We examined this in a community-based observational study, the Paris Prospective Study III (PPS3). Approach and Results: In 7626 adults aged 50 to 75 years, resting nBRS (estimated by low-frequency gain, from carotid distension rate and RR [time elapsed between two successive R waves] intervals) and mechanical BRS were measured by high-precision carotid echotracking. The associations between overt T2D or HMR as compared with subjects with normal glucose metabolism and nBRS or mechanical BRS were quantified using multivariable linear regression analysis. There were 319 subjects with T2D (61±6 years, 77% male), 1450 subjects with HMR (60±6 years, 72% male), and 5857 subjects with normal glucose metabolism (59±6 years, 57% male). Compared with normal glucose metabolism, nBRS was significantly lower in HMR subjects (β=-0.07 [95% CI, -0.12 to -0.01]; P=0.029) and in subjects with T2D (β=-0.18 [95% CI, -0.29 to -0.07]; P=0.002) after adjustment for confounding and mediating factors. Subgroup analysis suggests significant and independent alteration in mechanical BRS only among HMR patients who had both impaired fasting glucose and metabolic syndrome. CONCLUSIONS: In this community-based study of individuals aged 50 to 75, a graded decrease in nBRS was observed in HMR subjects and patients with overt T2D as compared with normal glucose metabolism subjects.
Authors: Joshua M Bock; William E Hughes; Kenichi Ueda; Andrew J Feider; Satoshi Hanada; Darren P Casey Journal: Am J Hypertens Date: 2022-09-01 Impact factor: 3.080
Authors: Nour-Mounira Z Bakkar; Haneen S Dwaib; Souha Fares; Ali H Eid; Yusra Al-Dhaheri; Ahmed F El-Yazbi Journal: Int J Mol Sci Date: 2020-11-27 Impact factor: 5.923
Authors: Lucas Raphael Bento Silva; Paulo Gentil; Camila Simões Seguro; Gabriela Teles de Oliveira; Maria Sebastiana Silva; Antônio Roberto Zamunér; Thomas Beltrame; Ana Cristina Silva Rebelo Journal: Front Endocrinol (Lausanne) Date: 2021-11-09 Impact factor: 5.555
Authors: Lina T Al Kury; Stephanie Chacar; Eman Alefishat; Ali A Khraibi; Moni Nader Journal: Front Endocrinol (Lausanne) Date: 2022-07-07 Impact factor: 6.055