Ping Wu1, Fang Zeng1, Canxin Yin1, Yan Xiong1, Yu Bai1, Dan Wang1, Yume Zhou1, Fanrong Liang1, Yongxin Li2, Ji Li3, Lihua Qiu4, Wei Qin5, Lu Luo6. 1. Department of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China. 2. Institute of Clinical Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangdong, Guangzhou 510515, China. 3. Department of Acupuncture and Rehabilitation, The First Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China. 4. Radiology Department, West China Hospital of Sichuan University, Chengdu 600075, China. 5. Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an 710071, China. 6. China Academy of Chinese Medical Sciences, World Federation of Acupuncture-Moxibustion Societies, Beijing 100061, China.
Abstract
OBJECTIVE: To determine differences in cerebral activity evoked by acupuncture and conventional stroke treatment, and identify the treatment targets. METHODS: In total, 21 patients were randomly divided into two groups. Group A (11 patients) received both acupuncture and conventional treatment, while group B (10 patients) received conventional treatment only. Resting-state functional magnetic resonance imaging (fMRI) was performed on each participant before and after treatment. Regional homogeneity analysis was performed to investigate the potential mechanism of acupuncture treatment by comparing differences in cerebral activity between treatments. RESULTS: Group A showed higher ReHo in the frontal lobe (BA6, BA46), supra-marginal gyrus (BA40), middle temporal gyrus (BA21), cerebellum, and insula. Group B showed higher ReHo in the frontal lobe (BA6) and parietal lobe (BA3, BA7). CONCLUSION:Acupuncture and conventional treatment triggered relatively different clinical efficacy and brain responses. Acupuncture treatment more significantly improved the symptoms of stroke patients. More marked changes in sensory, emotional, and motor areas (including the frontal lobe, middle temporal gyrus, cerebellum, and insula) might reflect the specific acupuncture mechanism.
RCT Entities:
OBJECTIVE: To determine differences in cerebral activity evoked by acupuncture and conventional stroke treatment, and identify the treatment targets. METHODS: In total, 21 patients were randomly divided into two groups. Group A (11 patients) received both acupuncture and conventional treatment, while group B (10 patients) received conventional treatment only. Resting-state functional magnetic resonance imaging (fMRI) was performed on each participant before and after treatment. Regional homogeneity analysis was performed to investigate the potential mechanism of acupuncture treatment by comparing differences in cerebral activity between treatments. RESULTS: Group A showed higher ReHo in the frontal lobe (BA6, BA46), supra-marginal gyrus (BA40), middle temporal gyrus (BA21), cerebellum, and insula. Group B showed higher ReHo in the frontal lobe (BA6) and parietal lobe (BA3, BA7). CONCLUSION: Acupuncture and conventional treatment triggered relatively different clinical efficacy and brain responses. Acupuncture treatment more significantly improved the symptoms of strokepatients. More marked changes in sensory, emotional, and motor areas (including the frontal lobe, middle temporal gyrus, cerebellum, and insula) might reflect the specific acupuncture mechanism.