Christian Akuodor Godwin1, Chile Asika Ebere1, Nwobodo Nwobodo Ndubuisi1, Thecla Ezeonu Chinonyelum2, Dick Essien Augustine3, Chimsorom Chilaka Kingsley4, Ckukwu Nwachukwu Daniel5. 1. Department of Pharmacology and Therapeutics, Faculty of Medicine, Ebonyi State University, Abakaliki P.M.B. 053, Nigeria. 2. Department of Paediatrics, Faculty of Medicine, Ebonyi State University, Abakaliki P.M.B. 053, Nigeria. 3. Department of Pharmacology, College of Medical Sciences, University of Calabar, Calabar P.M.B. 1115, Nigeria. 4. Department of Pharmacology and Therapeutics, College of Health Sciences, Nnamdi Azikiwe University, Awka P.M.B. 5025, Nigeria. 5. Department of Physiology, College of Medicine, University of Nigeria, Enugu P.M.B. 1011, Nigeria.
Abstract
OBJECTIVE: To evaluate the in vivo antiplasmodial activity and the oral acute toxicity of the Bombax buonopozense root bark aqueous extract. METHODS: The in vivo antiplasmodial activity of the root bark aqueous extract of Bombax buonopozense against early and established rodent malaria infections in chloroquine sensitive Plasmodium berghei strain in mice was investigated, and oral acute toxicity of the aqueous root bark extract of Bombax buonopozense was also evaluated in mice. RESULTS: The findings of this study revealed significant (P < 0.05) and dose dependent decrease in parasitaemia in the parasitized groups treated with varying doses of the extract (50-200 mg/kg p.o.) in both suppressive and curative tests. There was also significant decrease in parasitaemia density in the chloroquine treated group. The aqueous extract was found no toxicity in mice and the oral LD50 was determined to be greater than 5000 mg/kg. CONCLUSION: Bombax buonopozense root bark aqueous extract possesses potent antiplasmodial activity and may therefore, serve as potential sources of new antimalarial agents.
OBJECTIVE: To evaluate the in vivo antiplasmodial activity and the oral acute toxicity of the Bombax buonopozense root bark aqueous extract. METHODS: The in vivo antiplasmodial activity of the root bark aqueous extract of Bombax buonopozense against early and established rodent malaria infections in chloroquine sensitive Plasmodium berghei strain in mice was investigated, and oral acute toxicity of the aqueous root bark extract of Bombax buonopozense was also evaluated in mice. RESULTS: The findings of this study revealed significant (P < 0.05) and dose dependent decrease in parasitaemia in the parasitized groups treated with varying doses of the extract (50-200 mg/kg p.o.) in both suppressive and curative tests. There was also significant decrease in parasitaemia density in the chloroquine treated group. The aqueous extract was found no toxicity in mice and the oral LD50 was determined to be greater than 5000 mg/kg. CONCLUSION:Bombax buonopozense root bark aqueous extract possesses potent antiplasmodial activity and may therefore, serve as potential sources of new antimalarial agents.