Pamela J Surkan1, Ruibin Wang2, Yuru Huang2, Ron Stall3, Michael Plankey4, Linda A Teplin5, Richard G Wight6, Lisa P Jacobson2, Alison G Abraham2,7. 1. Social and Behavioral Interventions Program, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. 2. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. 3. Department of Behavioral and Community Health Sciences, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania. 4. Department of Medicine, Georgetown University Medical Center, Washington, District of Columbia. 5. Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois. 6. Department of Community Health Sciences, University of California Los Angeles Fielding School of Public Health, Los Angeles, California. 7. Department of Ophthalmology, Johns Hopkins School of Medicine, Baltimore, Maryland.
Abstract
Purpose: We investigated the relation between adversities in early adolescence and risk of a depressive phenotype in adulthood, and whether stress in adulthood modified these associations. Methods: A total of 1138 men who have sex with men (MSM) participated in a Multicenter AIDS Cohort substudy in which they reported on adversities in early adolescence. Poisson regression estimated prevalence ratios (PRs) for associations between adversities and a depressive phenotype in adulthood. Stratified analyses examined the effects of stress in the last year on the depressive phenotype. Results: In adjusted models, men who were verbally insulted; threatened by physical violence; had an object thrown at them; or punched, kicked, or beaten were at higher risk of having a depressive phenotype in adulthood (for ≥1 time per month vs. never, PR = 1.50, 95% confidence interval [CI] = 1.15-1.96; PR = 1.84, 95% CI = 1.45-2.34; PR = 2.00, 95% CI = 1.51-2.66; or PR = 1.78, 95% CI = 1.35-2.34, respectively.) Being threatened with a weapon approached statistical significance (PR = 1.89, 95% CI = 0.96-3.72). Although higher stress was associated with depression overall, early adolescent victimization was only associated with depression among MSM not reporting high levels of stress in the last year (for ≥1 time per month vs. never, PR = 1.68, 95% CI = 1.09-2.59; PR = 2.11, 95% CI = 1.40-3.17; PR = 2.24, 95% CI = 1.24-4.03; PR = 1.98, 95% CI = 1.22-3.22, respectively). Conclusion: The attenuation of relationships between adversities and depression among men reporting high stress may suggest that adult stress overshadows long-term effects of early adolescent victimization on adult depression. Victimization in early adolescence may increase the risk of sustained depressive symptoms in mid- to later life, reinforcing the need for preventive strategies.
Purpose: We investigated the relation between adversities in early adolescence and risk of a depressive phenotype in adulthood, and whether stress in adulthood modified these associations. Methods: A total of 1138 men who have sex with men (MSM) participated in a Multicenter AIDS Cohort substudy in which they reported on adversities in early adolescence. Poisson regression estimated prevalence ratios (PRs) for associations between adversities and a depressive phenotype in adulthood. Stratified analyses examined the effects of stress in the last year on the depressive phenotype. Results: In adjusted models, men who were verbally insulted; threatened by physical violence; had an object thrown at them; or punched, kicked, or beaten were at higher risk of having a depressive phenotype in adulthood (for ≥1 time per month vs. never, PR = 1.50, 95% confidence interval [CI] = 1.15-1.96; PR = 1.84, 95% CI = 1.45-2.34; PR = 2.00, 95% CI = 1.51-2.66; or PR = 1.78, 95% CI = 1.35-2.34, respectively.) Being threatened with a weapon approached statistical significance (PR = 1.89, 95% CI = 0.96-3.72). Although higher stress was associated with depression overall, early adolescent victimization was only associated with depression among MSM not reporting high levels of stress in the last year (for ≥1 time per month vs. never, PR = 1.68, 95% CI = 1.09-2.59; PR = 2.11, 95% CI = 1.40-3.17; PR = 2.24, 95% CI = 1.24-4.03; PR = 1.98, 95% CI = 1.22-3.22, respectively). Conclusion: The attenuation of relationships between adversities and depression among men reporting high stress may suggest that adult stress overshadows long-term effects of early adolescent victimization on adult depression. Victimization in early adolescence may increase the risk of sustained depressive symptoms in mid- to later life, reinforcing the need for preventive strategies.
Entities:
Keywords:
HIV; MSM; depression; early adolescence; stress victimization
Authors: Jane M Gunn; Darshini R Ayton; Konstancja Densley; Julie F Pallant; Patty Chondros; Helen E Herrman; Christopher F Dowrick Journal: Soc Psychiatry Psychiatr Epidemiol Date: 2010-12-25 Impact factor: 4.328
Authors: Kate M Scott; Michael Von Korff; Matthias C Angermeyer; Corina Benjet; Ronny Bruffaerts; Giovanni de Girolamo; Josep Maria Haro; Jean-Pierre Lépine; Johan Ormel; José Posada-Villa; Hisateru Tachimori; Ronald C Kessler Journal: Arch Gen Psychiatry Date: 2011-08
Authors: Nicole M Armstrong; Pamela J Surkan; Glenn J Treisman; Ned C Sacktor; Michael R Irwin; Linda A Teplin; Ron C Stall; Lisa P Jacobson; Alison G Abraham Journal: Aging Ment Health Date: 2018-02-09 Impact factor: 3.658
Authors: Andrea L Roberts; Margaret Rosario; Natalie Slopen; Jerel P Calzo; S Bryn Austin Journal: J Am Acad Child Adolesc Psychiatry Date: 2012-12-28 Impact factor: 8.829
Authors: Thomas C Mills; Jay Paul; Ron Stall; Lance Pollack; Jesse Canchola; Y Jason Chang; Judith T Moskowitz; Joseph A Catania Journal: Am J Psychiatry Date: 2004-02 Impact factor: 18.112
Authors: Andres R Schneeberger; Michael F Dietl; Kristina H Muenzenmaier; Christian G Huber; Undine E Lang Journal: Soc Psychiatry Psychiatr Epidemiol Date: 2014-03-19 Impact factor: 4.328