| Literature DB >> 32185901 |
Isabel Dos Santos Souza1,2,3, Nawal Maïssa1,2,3, Jason Ziveri1,2,3, Philippe C Morand1,2,3, Mathieu Coureuil3,4,5, Xavier Nassif3,4,5,6, Sandrine Bourdoulous1,2,3.
Abstract
Neisseria meningitidis (meningococcus) is a Gram-negative bacterium responsible for two devastating forms of invasive diseases: purpura fulminans and meningitis. Interaction with both peripheral and cerebral microvascular endothelial cells is at the heart of meningococcal pathogenesis. During the last two decades, an essential role for meningococcal type IV pili in vascular colonisation and disease progression has been unravelled. This review summarises 20 years of research on meningococcal type IV pilus-dependent virulence mechanisms, up to the identification of promising anti-virulence compounds that target type IV pili.Entities:
Keywords: zzm321990Neisseria meningitidis; adhesion; cell signalling; pathogenesis; therapeutic target; type IV pili; virulence
Mesh：
Year: 2020 PMID： 32185901 DOI： 10.1111/cmi.13185
Source DB: PubMed Journal: Cell Microbiol ISSN： 1462-5814 Impact factor: 3.715