Yue Zhang1,2, Jian Chen1,2, Xunyao Hou1,2, Yunliang Guo1,2, Renjun Lv1,2, Song Xu1,2, Shanjing Nie1,2, Xueping Liu3,4,5. 1. Department of Senile Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, People's Republic of China. 2. Anti-Aging Monitoring Laboratory, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, People's Republic of China. 3. Department of Senile Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, People's Republic of China. Liuxueping1962@163.com. 4. Anti-Aging Monitoring Laboratory, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, People's Republic of China. Liuxueping1962@163.com. 5. Department of Anti-Aging, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, People's Republic of China. Liuxueping1962@163.com.
Abstract
PURPOSE: According to the cognitive processing perspectives, patients with insomnia have insufficient neural management of expressional information. In this study, we compared the pre-attentive processing function of task-irrelevant facial expressions in patients with primary insomnia (PI) and matched healthy controls, with expression-related mismatch negativity (EMMN) elicited by emotional faces as the indicator. METHODS: Using three schematic facial expressions (neutral, happy, and sad) as task-irrelevant stimuli, we investigated the visual processing of PI patients (n = 22) and healthy subjects (n = 22) in an expression-related oddball paradigm designed to elicit the visual N170 and EMMN component. After recording and analyzing the electroencephalogram of all participants, amplitude analysis of N170 and EMMN was eventually conducted under corresponding time window. RESULTS: Compared with control group, the amplitude of sad-EMMN component was significantly attenuated in patients with PI, while no remarkable difference was observed under the happy condition. In addition, negative cognitive bias was further validated in the control group, but not presented in the PI group. CONCLUSION: The current data suggest dysfunctional expressional information processing in PI patients, accompanied by the disorganization of high level perceptual strategy of processing facial emotional expression.
PURPOSE: According to the cognitive processing perspectives, patients with insomnia have insufficient neural management of expressional information. In this study, we compared the pre-attentive processing function of task-irrelevant facial expressions in patients with primary insomnia (PI) and matched healthy controls, with expression-related mismatch negativity (EMMN) elicited by emotional faces as the indicator. METHODS: Using three schematic facial expressions (neutral, happy, and sad) as task-irrelevant stimuli, we investigated the visual processing of PIpatients (n = 22) and healthy subjects (n = 22) in an expression-related oddball paradigm designed to elicit the visual N170 and EMMN component. After recording and analyzing the electroencephalogram of all participants, amplitude analysis of N170 and EMMN was eventually conducted under corresponding time window. RESULTS: Compared with control group, the amplitude of sad-EMMN component was significantly attenuated in patients with PI, while no remarkable difference was observed under the happy condition. In addition, negative cognitive bias was further validated in the control group, but not presented in the PI group. CONCLUSION: The current data suggest dysfunctional expressional information processing in PIpatients, accompanied by the disorganization of high level perceptual strategy of processing facial emotional expression.
Authors: Xiao-Lan Cao; Shi-Bin Wang; Bao-Liang Zhong; Ling Zhang; Gabor S Ungvari; Chee H Ng; Lu Li; Helen F K Chiu; Grace K I Lok; Jian-Ping Lu; Fu-Jun Jia; Yu-Tao Xiang Journal: PLoS One Date: 2017-02-24 Impact factor: 3.240
Authors: Charles M Morin; Christopher L Drake; Allison G Harvey; Andrew D Krystal; Rachel Manber; Dieter Riemann; Kai Spiegelhalder Journal: Nat Rev Dis Primers Date: 2015-09-03 Impact factor: 65.038