Mao-Tong Liu1, Xue-Qin Zhang2, Jian Lu3, Tao Zhang1, Qi Chen4, Ji-Feng Jiang1, Ding Ding1, Sheng Du1, Wei-Bo Chen5. 1. Department of Radiology, Affiliated Nantong Hospital 3 of Nantong University, #99 Youth Middle Road, Chongchuan District, Nantong, 226000, Jiangsu, China. 2. Department of Radiology, Affiliated Nantong Hospital 3 of Nantong University, #99 Youth Middle Road, Chongchuan District, Nantong, 226000, Jiangsu, China. 13962981245@163.com. 3. Department of Radiology, Affiliated Nantong Hospital 3 of Nantong University, #99 Youth Middle Road, Chongchuan District, Nantong, 226000, Jiangsu, China. whg678@sina.com. 4. Nantong University, #19 Qixiu Road, Chongchuan District, Nantong, 226000, Jiangsu, China. 5. Philips Healthcare, Shanghai, China.
Abstract
OBJECTIVES: This study aimed to evaluate the feasibility of using the hepatocyte enhancement fraction (HEF) based on gadoxetic acid-enhanced magnetic resonance imaging (MRI) for assessing the liver function in patients with chronic hepatitis B. METHODS: Sixty patients with Child-Pugh grade A (CP-A), 18 with Child-Pugh grade B (CP-B), 2 with Child-Pugh grade C (CP-C), and 20 with normal liver function (NLF) were enrolled. Gadolinium ethoxybenzyldiethy-lenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced MRI was conducted. T1 mapping imaging was performed before and 20 min after Gd-EOB-DTPA administration. The pre- and post-contrast T1 values of the liver (T1pre and T1post), increase in the T1 relaxation rate (ΔR1), rate of decrease in the T1 relaxation time (ΔT1), HEF, and uptake coefficient (K) parameters in the NLF, CP-A, and CP-B + CP-C groups were compared using one-way analysis of variance. The effectiveness of each parameter in differentiating the NLF + CP-A group from the CP-B + CP-C group was evaluated using the receiver operating characteristic (ROC) curve. RESULTS: The HEF, K, ΔT1, and ΔR1 values decreased, while the T1post and T1pre values increased, with the increase in liver function damage. Significant differences in T1post, ΔT1, ΔR1, and HEF were found between different groups, except for the CP-A and NLF groups. However, no significant difference was observed in the T1pre among the three groups. HEF exhibited the largest area under the ROC curve. CONCLUSION: The HEF is an effective method for evaluating liver function in patients with hepatitis B.
OBJECTIVES: This study aimed to evaluate the feasibility of using the hepatocyte enhancement fraction (HEF) based on gadoxetic acid-enhanced magnetic resonance imaging (MRI) for assessing the liver function in patients with chronic hepatitis B. METHODS: Sixty patients with Child-Pugh grade A (CP-A), 18 with Child-Pugh grade B (CP-B), 2 with Child-Pugh grade C (CP-C), and 20 with normal liver function (NLF) were enrolled. Gadolinium ethoxybenzyldiethy-lenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced MRI was conducted. T1 mapping imaging was performed before and 20 min after Gd-EOB-DTPA administration. The pre- and post-contrast T1 values of the liver (T1pre and T1post), increase in the T1 relaxation rate (ΔR1), rate of decrease in the T1 relaxation time (ΔT1), HEF, and uptake coefficient (K) parameters in the NLF, CP-A, and CP-B + CP-C groups were compared using one-way analysis of variance. The effectiveness of each parameter in differentiating the NLF + CP-A group from the CP-B + CP-C group was evaluated using the receiver operating characteristic (ROC) curve. RESULTS: The HEF, K, ΔT1, and ΔR1 values decreased, while the T1post and T1pre values increased, with the increase in liver function damage. Significant differences in T1post, ΔT1, ΔR1, and HEF were found between different groups, except for the CP-A and NLF groups. However, no significant difference was observed in the T1pre among the three groups. HEF exhibited the largest area under the ROC curve. CONCLUSION: The HEF is an effective method for evaluating liver function in patients with hepatitis B.
Entities:
Keywords:
Gd-EOB-DTPA; Liver function; Magnetic resonance imaging
Authors: Verena Carola Obmann; Damiano Catucci; Annalisa Berzigotti; Christoph Gräni; Lukas Ebner; Johannes Thomas Heverhagen; Andreas Christe; Adrian Thomas Huber Journal: Sci Rep Date: 2022-03-18 Impact factor: 4.379
Authors: Ute Lina Fahlenkamp; Katharina Ziegeler; Lisa Christine Adams; Sarah Maria Böker; Günther Engel; Marcus Richard Makowski Journal: Sci Rep Date: 2020-10-22 Impact factor: 4.379