Number of Electroconvulsive Therapy Sessions required for Thai Psychiatric Patients: a Retrospective Study.

OBJECTIVE: To study predictors of the number of electroconvulsive therapy (ECT) sessions required for symptom remission in psychiatric patients. PATIENTS AND METHODS: We conducted chart reviews for 95 patients whose condition remitted following inpatient ECT. We analyzed the clinical characteristics of the patients and compared the number of ECT sessions between adult (age 18-59 years) and elderly (age ≥ 60 years) patients.
RESULTS: The overall mean ± SD of the number of ECT sessions was 11.8 ± 4.7 (range: 6-24). By diagnosis, it was 13.3 ± 5.5 for individuals with schizophrenia, 10.1 ± 2.7 for schizoaffective disorder, 14.4 ± 5.6 for bipolar depression, 9.4 ± 1.9 for bipolar mania, 10.9 ± 4.3 for major depressive disorder (MDD), and 11.8 ± 4.3 for those with other diagnoses. For MDD, the number of ECT sessions in elderly patients (13.4 ± 4.6) was statistically greater than that in adult patients (9 ± 2.9) (p = 0.008).
CONCLUSION: The number of ECT sessions varied by age and diagnosis. The number of ECT sessions in elderly MDD patients was higher than that in adult MDD patients.

Introduction

Electroconvulsive therapy (ECT) has been used to treat psychiatric conditions since the 1940s. ECT is beneficial for patients who require a rapid treatment response and have not responded adequately to pharmacotherapy. For acute treatment, a typical ECT course involves 6–12 treatments.1–3 ECT is usually stopped when patients achieve remission or the clinical effect plateaus (ie, no additional benefits are observed for two or three successive ECT sessions). When remission is achieved, maintenance ECT is suggested for some patients to prevent the relapse of psychiatric symptoms.

The number of acute ECT treatments applied is highly variable in different settings,4 and should be determined according to the severity of illness and benefits and risks of treatment.2 Previous studies have indicated that psychiatric diagnosis, sex, age of onset, number of illness episodes, and changes in symptoms during ECT all contribute to this variability.5–8 A retrospective study of patients with treatment-resistant schizophrenia who received ECT with clozapine found that the mean number of treatments was 14 (range: 5–45).9 With respect to mood disorders, a previous study of hospitalized patients who received ECT found that the mean number of treatments needed to achieve remission in patients with bipolar depression (7.5) was lower than that in patients with unipolar depression (10.2).5 Pitidhammabhorn et al reported that psychiatric inpatients received a mean of 8.6 ECT sessions (range: 1–24), and that the number of treatment sessions was similar across psychiatric diagnoses.10

To our knowledge, few studies have examined the number of ECT sessions and associated factors in Thai psychiatric patients. In Thailand, most psychiatrists tend to prescribe ECT as a last resort for patients who do not respond to other treatment modalities. Knowledge about ECT is helpful for clinicians when estimating the number of ECT sessions a patient may undergo and for informing patients and their caregivers regarding the estimated duration of ECT treatment. In the current study, we examined predictors of the number of ECT sessions required for symptom remission in psychiatric patients.

Patients and Methods

Setting and Study Design

The study protocol was approved by the Ethics Committee on Human Experimentation of the Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. Written informed consent was obtained from patients or their families. Research was conducted in accordance with the Declaration of Helsinki.

The study design was retrospective. We conducted chart reviews for all patients who received inpatient ECT from January 2013 to November 2018 at the institution. Psychiatric diagnoses were performed by psychiatrists based on the DSM-IV-TR11 criteria. Patients who discontinued ECT owing to any reasons other than the achievement of remission were excluded from the study. We collected demographic data, as well as information regarding clinical characteristics, physical and mental illness, and ECT data (eg, indications, stimulus dose, electrode placement method, and number of sessions). Psychiatric rating scales, including the Brief Psychiatric Rating Scale (BPRS)12,13 for schizophrenia, Montgomery Asberg Depression Rating Scale (MADRS)14,15 for depression, and Young Mania Rating Scale (YMRS)16,17 for mania, were used to assess the severity of symptoms at baseline (24 hrs before ECT), after every 3 sessions of ECT treatment, and after the last ECT session. The BPRS is an 18-item rating scale frequently used to assess the severity of symptoms in patients with schizophrenia. Each item is rated on a scale from 1 (symptom is not present) to 7 (extremely severe).13 The MADRS is a 10-item rating scale used to assess the severity of depressive symptoms.15 Each item is scored from 0 to 6. The YMRS is an 11-item rating scale used to assess the severity of manic symptoms.17 Each item is scored from 0 to 4. Assessments were performed by staff and psychiatric residents who had received appropriate training. Assessments of inter-rater reliability were performed using the Intraclass Correlation Coefficient (ICC). The ICC was 0.99. Remission was defined as follows: BPRS < 31 for schizophrenia,12 MADRS < 10 for depression,14 and YMRS < 10 for mania.16,17

ECT Treatment

All patients were assessed by psychiatrists and anesthesiologists before receiving ECT. Benzodiazepines were discontinued at least 15 hrs before treatment. The ECT procedures were performed at the post-anesthetic care unit (PACU) by the ECT team, which included psychiatric staff, psychiatric residents, anesthetic staff, psychiatric nurses, and anesthetic nurses. After administration of thiopental (1–6 mg/kg IV) or propofol (1–2 mg/kg IV) for anesthesia and succinylcholine (0.5–1 mg/kg IV), which is a muscle relaxant, ECT was conducted using a modified technique involving a brief pulse wave generated by a Mecta Spectrum 5000Q (Mecta Corp, USA) or Thymatron® System IV. ECT was performed three times per week.

The electrode placement was determined by the psychiatrists who prescribed ECT. The seizure threshold (ST) was determined at the first ECT session by empirically derived stimulus titration. The stimulus intensity was then increased to 500% above the ST for right unilateral (RUL) electrode placement and 50% above the ST for bilateral (BL) electrode placement.18 Treatment was typically stopped when maximal improvement was reached or when adverse effects limited further treatments. For analysis in this study, we included the number of ECT sessions from baseline until patients reached remission.

Statistical Analysis

We divided patients into a younger group (age 18–59 years) and an older group (age ≥ 60 years). We analyzed the clinical characteristics of the patients and compared the number of ECT sessions between adult and elderly patients. All statistical analysis was performed using SPSS 21.0 for Windows (IBM Corp., Armonk, NY, USA). Data were presented using the mean ± standard deviation (SD) and percentages for continuous and categorical outcomes, respectively. We assessed the data distribution to determine the appropriate statistical test. Continuous measures were compared using independent t-tests and a one-way ANOVA, as indicated. Categorical parameters were compared using chi-squared and Fisher’s exact tests, as indicated. Statistical significance was set such that the P-value < 0.05.

Results

Demographic Characteristics

One hundred and nineteen inpatients had received ECT treatment. Of this group, 95 patients (78%) achieved remission following ECT treatment. The clinical characteristics of the 95 patients are shown in Table 1. The group ranged in age from 18 to 81 years. We divided them into a younger group (18–59 years) and an older group (60–81 years). Approximately, 20% (19/95) of the patients were elderly (age ≥ 60 years). The most common diagnoses were schizophrenia (32/95, 33.7%), major depressive disorder (MDD) (25/95, 26.3%), and bipolar mania (14/95, 14.7%).

Table 1

Demographic Data (Total N = 95)

Characteristics	N (%) or Mean ± SD
Female (%)	60 (63.2%)
Age (years)	46.1 ± 15.7
< 60 years	76 (80%)
≥ 60 years	19 (20%)
Body mass index	25.1 ± 5.8
Diagnosis
Schizophrenia	32 (33.7%)
Schizoaffective disorder	10 (10.5%)
Bipolar disorder	24 (25.3%)
Major depressive disorder	25 (26.3%)
Other diagnosis	4 (4.2%)
Duration of illness	12.4 ± 9 (12.9)
History of previous ECT	25 (26.3%)
Concurrent medication
Benzodiazepine	4 (4.2%)
Antipsychotic	82 (86.3%)
Antidepressant	22 (23.2%)
Anticonvulsant	6 (6.3%)
Anticholinergic	12 (12.6%)
Electrode placement
Right unilateral	32 (33.7%)
Bilateral	63 (66.3%)

Abbreviations: SD, standard deviation; ECT, electroconvulsive therapy.

Number of ECT Sessions

The average overall number of ECT sessions was 11.8 ± 4.7, with a range of 6–24. The number of ECT sessions varied by diagnosis (Table 2). We found no significant differences in the number of ECT sessions by sex, history of previous ECT, concurrent medication in the 24 hrs before ECT, or electrode placement (Table 2). The mean ± SD number of ECT treatments in elderly patients (14.2 ± 4.7) was statistically higher than that in adult patients (11.2 ± 4.6) (t = −0.3, df = 93, p = 0.014).

Table 2

Number of ECT Sessions

Clinical Characteristics	N	Mean ± SDNumber of ECT Sessions	P value
Sex
Female	60	11.8 ± 4.9	0.942
Male	35	11.7 ± 4.6
Age
<60 years	76	11.2 ± 4.6	0.014*
≥60 years	19	14.2 ± 4.7
Diagnosis
Schizophrenia	32	13.3 ± 5.5	0.263
Schizoaffective disorder	10	10.1 ± 2.7
Bipolar disorder	24
Depression	10	14.4 ± 5.6
Mania	14	9.4 ± 1.9
Major depressive disorder	25	10.9 ± 4.3
Other diagnosis	4	11.8 ± 4.3
Body Mass Index (BMI)
Underweight (<18.5)	11	12 ± 6	0.998
Normal (18.5–25)	40	11.8 ± 4.2
Overweight (25–30)	30	11.8 ± 5.1
Obese (> 30)	14	11.6 ± 4.9
History of Previous ECT
No	70	11.6 ± 4.5	0.427
Yes	25	12.4 ± 5.4
Concurrent Medication
Benzodiazepine			0.103
No	91	12 ± 4.8
Yes	4	8 ± 1.4
Antipsychotic			0.937
No	13	11.7 ± 4.9
Yes	82	11.8 ± 4.7
Antidepressant
No	73	11.7 ± 4.8	0.853
Yes	82	12 ± 4.6
Anticonvulsant
No	89	11.7 ± 4.7	0.413
Yes	6	13.3 ± 5.4
Anticholinergic
No	83	11.9 ± 4.8	0.629
Yes	12	11.2 ± 4.7
Electrode Placement
Right unilateral	32	11.8 ± 4.3	0.973
Bilateral	63	11.8 ± 5

Note: *p < 0.05

Abbreviation: SD, standard deviation.

Number of ECT Treatments in Elderly versus Adult Patients

We compared the clinical characteristics of the elderly and adult patients (Table 3). The proportion of elderly patients with MDD (11/19, 57.9%) was significantly greater than that of the adult patients (14/76, 18.4%) (Chi-square = 12.2, df =1, p = 0.0047). The proportion of elderly patients who received RUL electrode placement (11/19, 57.9%) was greater than that of adult patients (21/76, 27.6%) (Chi-square = 6.2, df =1, p = 0.013).

Table 3

Clinical Characteristics of Elderly and Adult Patients

Characteristics	N (%) or Mean ± SD		P value
	Age < 60 Years (N = 76)	Age ≥ 60 Years (N =19)
Female (%)	50 (65.8%)	10 (52.6%)	0.301
Body mass index	25.5 ± 5.9	23.4 ± 5.5	0.153
Diagnosis
Schizophrenia	30 (39.5%)	2 (10.5%)
Schizoaffective disorder	9 (11.8%)	1 (5.3%)
Bipolar Disorder
Depression	7 (9.2%)	3 (15.8%)	0.008*
Mania	13 (17.7%)	1 (5.3%)
Major depressive disorder	14 (18.4%)	11 (57.9%)
Other diagnosis	3 (3.9%)	1 (5.3%)
Duration of illness	12.1 ± 8.6(23)	11.2 ± 10.7(6)	0.383
History of previous ECT	22 (28.9%)	3 (15.8%)	0.741
Concurrent Medication
Benzodiazepine	4 (5.3%)	0	0.58
Antipsychotic	68(89.5%)	14 (73.7%)	0.127
Antidepressant	14 (18.4%)	8 (42.1%)	0.029
Anticonvulsant	5 (6.6%)	1 (5.3%)	1
Anticholinergic	11 (14.5%)	1 (5.3%)	0.449
Electrode Placement
Right unilateral	21 (27.6%)	11 (57.9%)	0.013*
Bilateral	55 (72.4%)	8 (42.1%)
Dose of Anesthetic Agents (mg)
Thiopental (n = 66 versus n = 16)	195.1 ± 68	159.4 ± 73.5	0.067
Propofol (n = 10 versus n = 3)	105 ± 43.8	63.7 ± 5.5	0.149
Seizure threshold (mC)	113.9 ± 98.7	129.9 ± 121.1	0.549

Note: *p < 0.05

Abbreviations: SD, standard deviation; mg, milligrams; mC, millicoulombs.

In the elderly group, the mean ± SD number of ECT sessions was 14 for those with schizophrenia (n = 2), 13 for schizoaffective disorder (n = 1), 9 for bipolar mania (n = 1), 19.3 ± 5.7 for bipolar depression (n = 3), 13.4 ± 4.6 for major depressive disorder (n =11), and 14 for other diagnoses (n = 1) (F = 1.1, p = 0.419).

In the adult group, the number of ECT sessions was 13.2 ± 5.7 for those with schizophrenia (n = 30), 9.8 ± 2.6 for schizoaffective disorder (n = 9), 9.4 ± 2 for bipolar mania (n = 13), 12.3 ± 4.3 for bipolar depression (n = 7), 9 ± 2.9 for major depressive disorder (n = 14), and 11.2 ± 4.6 for other diagnoses (n = 3) (F = 2.7, p = 0.027).

The number of ECT sessions for elderly patients with MDD (13.4 ± 4.6) was statistically higher than that for adult patients with MDD (9 ± 2.9) (t = −2.9, df = 23, p = 0.008). There were no significant differences among the patients with other diagnoses (Figure 1). Furthermore, elderly patients with MDD had more severe depressive symptoms than adult patients. For MDD, the baseline mean ± SD MADRS scores of elderly patients and adult patients were 37 ± 10.8 and 28.3 ± 6.8, respectively (t = −2.3, df = 20, p = 0.033) (Table 4).

Figure 1

Number of ECT sessions in elderly vs adult patients by diagnosis (*p < 0.05).

Table 4

Psychiatric Symptom Scores at Baseline and Post-ECT Treatment

	Baseline		p value	Post ECT		p value
	Age < 60 Years (N = 76)	Age ≥ 60 Years (N =19)		Age < 60 Years (N = 76)	Age ≥ 60 Years (N =19)
Schizophrenia
BPRS	49.4 ± 17.6	69.5 ± 21.9	0.136	24.5 ± 6.4	23 ± 5.7	0.753
Schizoaffective Disorder
BPRS	49.7 ± 22.4	70	–	24 ± 5	33	–
YMRS	14 ± 12.8	10	–	3.3 ± 4.2	2	–
MADRS	14.1 ± 14.7	38	–	4 ± 3.7	8	–
Bipolar Depression
MADRS	26.8 ± 4.6	39.7 ± 8.5	0.029*	4.5 ± 2.0	6.3 ± 2.5	0.591
Bipolar Mania
YMRS	23.5 ± 13.2	41	-	1.8 ± 3	2	-
MDD
MADRS	28.3 ± 6.8	37 ± 10.8	0.033*	6.8 ± 6.2	8.1 ± 4.9	0.598
Others Diagnosis
BPRS	59.7 ± 24.5	56	–	32.7 ± 10.7	24	–
YMRS	13 ± 18.2	4	–	1.6 ± 2.1	2	–
MADRS	16 ± 2	32	–	4.3 ± 1.5	2	–

Note: *p < 0.05

Abbreviations: BPRS, Brief Psychiatric Rating Scale; YMRS, Young Mania Rating Scale; MADRS, Montgomery Asberg Depression Rating Scale; SD, standard deviation.

Discussion

As a result of our study, we found that the mean of the number of ECT sessions was 11.8 (range: 6–24) in remitting psychiatric patients. The number of ECT sessions was 13.3 for individuals with schizophrenia, 10.1 for schizoaffective disorder, 14.4 for bipolar depression, 9.4 for bipolar mania, 10.9 for major depressive disorder, and 11.8 for other diagnoses. Our data were consistent with those of a previous study conducted in Thailand. Specifically, the mean number of ECT sessions was in the same range, although this number was slightly higher in the present study.10 This may be explained by our decision to only include inpatients who achieved remission and to exclude patients who stopped ECT treatment earlier, such as those who were unable to tolerate adverse effects of ECT. Patients who could not tolerate adverse effects, especially cognitive decline, tended to stop ECT before achieving remission. However, this number of ECT sessions in the present study was consistent with global figures.19

We found that in individuals with MDD, the number of ECT treatments in elderly patients (age > 60 years) (13.4) was higher than that in adult patients (9). This result is in contrast with previous studies that found older age to be associated with faster remission in MDD patients.7,20,21 It is possible that the illness severity in the elderly patients in our study was greater than that in the adult patients (Table 3), and thus, that RUL electrode placement was used more frequently in elderly vs adult patients to prevent cognitive adverse effects. RUL electrode placement may have had a weaker effect such that more acute ECT sessions were needed to achieve remission.22 Another possible explanation is the potential differences in the course of MDD in adult vs elderly patients. A previous naturalistic study demonstrated that the time required to achieve remission in MDD patients increased with age.23 Although the difference was not statistically significant (p = 0.062), the number of treatments in elderly patients with bipolar depression (19.3) in the present study was larger than that in adult patients (12.3). The lack of significance may have been due to sample size limitations.

A strength of this study was that we explored age and psychiatric diagnosis as factors impacting the number of ECT sessions. However, this study has several limitations. First, the patients were all inpatients at a university hospital in Thailand, so the results should be interpreted with caution in terms of applicability to other settings. Second, other factors that were not identified in the present clinical sample might have influenced the number of ECT sessions (for example, comorbid physical disease and depression subtype). Third, the sample size was small for some of the subgroups, so we may have missed differences between diagnoses. Finally, additional factors that we did not analyze, such as changes in symptoms during ECT, could have influenced the number of ECT sessions. Thus, the influence of these factors may warrant further study.

Conclusion

We found that the number of ECT sessions varied according to age and diagnosis. The number of ECT sessions in elderly MDD patients was higher than that in adult MDD patients.