Conscientiousness mediates the link between brain structure and consideration of future consequence.

The individual difference in valuing immediate and future outcomes is referred to as consideration of future consequences (CFC, including CFC-Future [CFC-F] and CFC-Immediate [CFC-I]), which significantly influences daily behaviour. Although CFC is believed to be affected by brain features and personalities, the relational model of brain correlates, personalities and CFC has yet to be determined. This study was designed to explore the brain structure related to CFC-F and CFC-I and the mediating role of conscientiousness. We adopted a voxel-based morphometry study and used grey matter density (GMD) as an indication of brain structure. The results showed that GMD in the ventromedial prefrontal cortex (VMPFC) was positively associated with CFC-F; however, we did not find relevant regions affecting CFC-I. Furthermore, conscientiousness was found to mediate the relationship between GMD in the VMPFC and CFC-F. This study provides initial evidence concerning the neural basis of CFC-F and argues that the features of brain structure could be associated with CFC-F through related high-order personality traits. Additionally, the distinction between CFC-F and CFC-I may be based on differences in brain structure.