| Literature DB >> 32183952 |
Jie Xiong1, Bo-Wen Cui1, Nan Wang1, Yu-Ting Dai2, Hao Zhang3, Chao-Fu Wang4, Hui-Juan Zhong1, Shu Cheng1, Bin-Shen Ou-Yang4, Yu Hu5, Xi Zhang6, Bin Xu7, Wen-Bin Qian8, Rong Tao9, Feng Yan10, Jian-Da Hu11, Ming Hou12, Xue-Jun Ma13, Xin Wang14, Yuan-Hua Liu15, Zun-Min Zhu16, Xiao-Bin Huang17, Li Liu18, Chong-Yang Wu19, Li Huang20, Yun-Feng Shen21, Rui-Bin Huang22, Jing-Yan Xu23, Chun Wang24, De-Pei Wu25, Li Yu26, Jian-Feng Li1, Peng-Peng Xu1, Li Wang27, Jin-Yan Huang28, Sai-Juan Chen29, Wei-Li Zhao30.
Abstract
Natural killer/T cell lymphoma (NKTCL) is an aggressive and heterogeneous entity of non-Hodgkin lymphoma, strongly associated with Epstein-Barr virus (EBV) infection. To identify molecular subtypes of NKTCL based on genomic structural alterations and EBV sequences, we performed multi-omics study on 128 biopsy samples of newly diagnosed NKTCL and defined three prominent subtypes, which differ significantly in cell of origin, EBV gene expression, transcriptional signatures, and responses to asparaginase-based regimens and targeted therapy. Our findings thus identify molecular networks of EBV-associated pathogenesis and suggest potential clinical strategies on NKTCL.Entities:
Keywords: Epstein-Barr virus; MYC; RAS; RNA helicase; RNA sequencing; copy number variation; genomics; histone acetylation; natural killer/T cell lymphoma; programmed cell death protein-1
Year: 2020 PMID： 32183952 DOI： 10.1016/j.ccell.2020.02.005
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743