Ruben Schleberger1, Mario Jularic2, Tim Salzbrunn1, Claudia Hacke3, Jana M Schwarzl1, Boris A Hoffmann4, Daniel Steven5, Stephan Willems2, Marc D Lemoine1, Christian Meyer6,7. 1. Department of Cardiology-Electrophysiology, University Heart and Vascular Center, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. 2. Department of Cardiology, Asklepios Klinik St. Georg, Lohmühlenstr. 5, 20099, Hamburg, Germany. 3. Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. 4. Department of Electrophysiology, Asklepios Klinikum Harburg, Eißendorfer Pferdeweg 52, 21075, Hamburg, Germany. 5. Department of Electrophysiology, University Heart Center Cologne, University Hospital Cologne, Kerpener Str. 52, 50937, Cologne, Germany. 6. Department of Cardiology-Electrophysiology, University Heart and Vascular Center, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. c.mey@web.de. 7. DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany. c.mey@web.de.
Abstract
BACKGROUND: Catheter ablation of non-reentrant, commonly termed "idiopathic" ventricular arrhythmias (VA) is highly effective in patients without structural heart disease (SHD). Meanwhile, the outcome of catheter ablation of these arrhythmias in patients with SHD remains unclear. This study sought to characterize the outcome of patients with and without SHD undergoing catheter ablation of non-reentrant VA. METHODS: In this single-centre study the acute and long-term outcome of 266 consecutive patients undergoing catheter ablation of non-reentrant VA was investigated. In 41.0% of patients a SHD was present (n = 109, 80.7% male, age 59.1 ± 14.7 years), 59.0% had no SHD (n = 157; 44.0% male, age 49.9 ± 16.5 years). RESULTS: Acute procedural success (absence of spontaneous or provoked VA at the end of procedure and within 48 h after the procedure) was achieved in 89.9% of patients with SHD vs. 94.3% without SHD (p = 0.238). During a mean follow-up of 34.7 ± 15.1 months a repeat catheter ablation was performed in 19.6% of patients with SHD vs. 13.0% without SHD (p = 0.179). Patients with dilated cardiomyopathy (DCM) were the most likely to require a repeat ablation procedure (32.0% of patients with DCM vs. 13.0% without SHD; p = 0.022). Periprocedural complications occurred in 5.5% of patients with SHD vs. 5.7% without SHD (p > 0.999). All complications were managed without sequelae. CONCLUSIONS: The outcome of catheter ablation of non-reentrant VA in patients with SHD appears good and is comparable to patients without SHD. A slightly higher rate of repeat ablations was observed in patients with DCM.
BACKGROUND: Catheter ablation of non-reentrant, commonly termed "idiopathic" ventricular arrhythmias (VA) is highly effective in patients without structural heart disease (SHD). Meanwhile, the outcome of catheter ablation of these arrhythmias in patients with SHD remains unclear. This study sought to characterize the outcome of patients with and without SHD undergoing catheter ablation of non-reentrant VA. METHODS: In this single-centre study the acute and long-term outcome of 266 consecutive patients undergoing catheter ablation of non-reentrant VA was investigated. In 41.0% of patients a SHD was present (n = 109, 80.7% male, age 59.1 ± 14.7 years), 59.0% had no SHD (n = 157; 44.0% male, age 49.9 ± 16.5 years). RESULTS: Acute procedural success (absence of spontaneous or provoked VA at the end of procedure and within 48 h after the procedure) was achieved in 89.9% of patients with SHD vs. 94.3% without SHD (p = 0.238). During a mean follow-up of 34.7 ± 15.1 months a repeat catheter ablation was performed in 19.6% of patients with SHD vs. 13.0% without SHD (p = 0.179). Patients with dilated cardiomyopathy (DCM) were the most likely to require a repeat ablation procedure (32.0% of patients with DCM vs. 13.0% without SHD; p = 0.022). Periprocedural complications occurred in 5.5% of patients with SHD vs. 5.7% without SHD (p > 0.999). All complications were managed without sequelae. CONCLUSIONS: The outcome of catheter ablation of non-reentrant VA in patients with SHD appears good and is comparable to patients without SHD. A slightly higher rate of repeat ablations was observed in patients with DCM.
Authors: M Nies; R Schleberger; L Dinshaw; N Klatt; P Muenkler; C Jungen; L Rottner; M D Lemoine; B Reißmann; A Rillig; A Metzner; P Kirchhof; C Meyer Journal: BMC Cardiovasc Disord Date: 2022-07-13 Impact factor: 2.174
Authors: Shinwan Kany; Fares Alexander Alken; Ruben Schleberger; Jakub Baran; Armin Luik; Annika Haas; Elena Ene; Thomas Deneke; L Dinshaw; Andreas Rillig; Andreas Metzner; Bruno Reissmann; Hisaki Makimoto; Tilko Reents; Miruna Andrea Popa; Isabel Deisenhofer; Roman Piotrowski; Piotr Kulakowski; Paulus Kirchhof; Katharina Scherschel; Christian Meyer Journal: Europace Date: 2022-07-15 Impact factor: 5.486
Authors: Ruben Schleberger; Jan Riess; Anika Brauer; Hans O Pinnschmidt; Laura Rottner; Fabian Moser; Julia Moser; Shinwan Kany; Ilaria My; Marc D Lemoine; Bruno Reissmann; Christian Meyer; Andreas Metzner; Feifan Ouyang; Paulus Kirchhof; Andreas Rillig Journal: Front Cardiovasc Med Date: 2022-05-25