Literature DB >> 32180540

A Subset of Equine Gastric Squamous Cell Carcinomas Is Associated With Equus Caballus Papillomavirus-2 Infection.

Elizabeth Alloway1, Keith Linder1, Susan May1, Trevor Rose1, Josepha DeLay2, Susan Bender3, Alison Tucker4, Jennifer Luff1.   

Abstract

Squamous cell carcinoma (SCC) is the most common neoplasm of the equine stomach. However, the mechanisms underlying malignant transformation are unknown. As Equus caballus papillomavirus-2 (EcPV-2) is a likely cause of some genital SCCs, we hypothesized that EcPV-2 is associated with a subset of equine gastric SCCs. To this aim, we performed polymerase chain reaction (PCR) and in situ hybridization (ISH) for EcPV-2 E6/ E7 oncogenes on 11 gastric SCCs and on gastric samples from 15 control horses with no SCC. PCR for EcPV-2 was positive in 7/11 (64%) gastric SCCs; non-SCC gastric samples were all negative. Intense hybridization signals for EcPV-2 E6/E7 nucleic acid were detected by ISH within tumor cells in 5/11 (45%) gastric SCCs, including distant metastases. No hybridization signals were detected within any of the non-SCC gastric cases. This study provides support for a potential association between EcPV-2 infection and a subset of equine gastric SCC.

Entities:  

Keywords:  Equus caballus papillomavirus; horses; in situ hybridization; oncogenic viruses; squamous cell carcinoma; stomach

Mesh：

Substances：

Year:  2020        PMID： 32180540      PMCID： PMC7335262          DOI： 10.1177/0300985820908797

Source DB:  PubMed          Journal:  Vet Pathol        ISSN： 0300-9858            Impact factor:   2.221


  10 in total

1.  Equine penile squamous cell carcinomas are associated with the presence of equine papillomavirus type 2 DNA sequences.

Authors:  C G Knight; J S Munday; J Peters; M Dunowska
Journal:  Vet Pathol       Date:  2011-01-31       Impact factor: 2.221

2.  EcPV-2 is transcriptionally active in equine SCC but only rarely detectable in swabs and semen from healthy horses.

Authors:  Sabine Sykora; Lisa Samek; Katharina Schönthaler; Franziska Palm; Giuseppe Borzacchiello; Christine Aurich; Sabine Brandt
Journal:  Vet Microbiol       Date:  2012-02-14       Impact factor: 3.293

3.  Equine Genital Squamous Cell Carcinoma: In Situ Hybridization Identifies a Distinct Subset Containing Equus caballus Papillomavirus 2.

Authors:  K W Zhu; V K Affolter; A M Gaynor; F N Dela Cruz; P A Pesavento
Journal:  Vet Pathol       Date:  2015-05-12       Impact factor: 2.221

4.  Equine papillomavirus type 2: An equine equivalent to human papillomavirus 16?

Authors:  S Sykora; C Jindra; M Hofer; R Steinborn; S Brandt
Journal:  Vet J       Date:  2017-05-03       Impact factor: 2.688

5.  EcPV2 DNA in equine papillomas and in situ and invasive squamous cell carcinomas supports papillomavirus etiology.

Authors:  C E Lange; K Tobler; A Lehner; P Grest; M M Welle; C C Schwarzwald; C Favrot
Journal:  Vet Pathol       Date:  2012-10-11       Impact factor: 2.221

6.  Gastric neoplasia in horses.

Authors:  S D Taylor; G J Haldorson; B Vaughan; N Pusterla
Journal:  J Vet Intern Med       Date:  2009-07-28       Impact factor: 3.333

7.  Comparison of the levels of Equus caballus papillomavirus type 2 (EcPV-2) DNA in equine squamous cell carcinomas and non-cancerous tissues using quantitative PCR.

Authors:  Cameron G Knight; Magda Dunowska; John S Munday; Jeanine Peters-Kennedy; Brielle V Rosa
Journal:  Vet Microbiol       Date:  2013-06-20       Impact factor: 3.293

8.  Gastric squamous cell carcinoma and gastric adenosquamous carcinoma, clinical features and outcomes of rare clinical entities: a National Cancer Database (NCDB) analysis.

Authors:  Mehmet Akce; Renjian Jiang; Olatunji B Alese; Walid L Shaib; Christina Wu; Madhusmita Behera; Bassel F El-Rayes
Journal:  J Gastrointest Oncol       Date:  2019-02

Review 9.  A Review of HPV-Related Head and Neck Cancer.

Authors:  Kazuhiro Kobayashi; Kenji Hisamatsu; Natsuko Suzui; Akira Hara; Hiroyuki Tomita; Tatsuhiko Miyazaki
Journal:  J Clin Med       Date:  2018-08-27       Impact factor: 4.241

Review 10.  Mucosal and Cutaneous Human Papillomavirus Infections and Cancer Biology.

Authors:  Tarik Gheit
Journal:  Front Oncol       Date:  2019-05-08       Impact factor: 6.244
  10 in total
  6 in total

1.  Detection of Equus caballus papillomavirus-2 in equine penile/preputial papillomas and squamous cell carcinomas in southern Brazil.

Authors:  Tanara Raquel de Oliveira da Silva; Paula Nitiana Campos Gonçalves; Valentina Berté Marcus; Carolina Isabela Mucellini; Igor Ribeiro Dos Santos; Glaucia Kommers; David Driemeier; Eduardo Furtado Flores; Juliana Felipetto Cargnelutti; Mariana M Flores
Journal:  Braz J Microbiol       Date:  2022-05-16       Impact factor: 2.214

2.  Epithelial to Mesenchymal Transition (EMT) in a Laryngeal Squamous Cell Carcinoma of a Horse: Future Perspectives.

Authors:  Federico Armando; Francesco Godizzi; Elisabetta Razzuoli; Fabio Leonardi; Mario Angelone; Attilio Corradi; Daniela Meloni; Luca Ferrari; Benedetta Passeri
Journal:  Animals (Basel)       Date:  2020-12-07       Impact factor: 2.752

Review 3.  Equine Squamous Gastric Disease: Prevalence, Impact and Management.

Authors:  Michael Hewetson; Rose Tallon
Journal:  Vet Med (Auckl)       Date:  2021-12-31

4.  Equus caballus Papillomavirus Type-9 (EcPV9): First Detection in Asymptomatic Italian Horses.

Authors:  Livia De Paolis; Chiara Grazia De Ciucis; Simone Peletto; Katia Cappelli; Samanta Mecocci; Tiziana Nervo; Lisa Guardone; Maria Ines Crescio; Daniele Pietrucci; Floriana Fruscione; Federica Gabbianelli; Silvia Turco; Katia Varello; Gian Guido Donato; Cristiana Maurella; Paola Modesto; Maria Grazia Maniaci; Giovanni Chillemi; Alessandro Ghelardi; Elisabetta Razzuoli
Journal:  Viruses       Date:  2022-09-15       Impact factor: 5.818

5.  Equine Penile Squamous Cell Carcinomas as a Model for Human Disease: A Preliminary Investigation on Tumor Immune Microenvironment.

Authors:  Ilaria Porcellato; Samanta Mecocci; Luca Mechelli; Katia Cappelli; Chiara Brachelente; Marco Pepe; Margherita Orlandi; Rodolfo Gialletti; Benedetta Passeri; Angelo Ferrari; Paola Modesto; Alessandro Ghelardi; Elisabetta Razzuoli
Journal:  Cells       Date:  2020-10-27       Impact factor: 6.600

6.  Equine Genital Squamous Cell Carcinoma Associated with EcPV2 Infection: RANKL Pathway Correlated to Inflammation and Wnt Signaling Activation.

Authors:  Samanta Mecocci; Ilaria Porcellato; Federico Armando; Luca Mechelli; Chiara Brachelente; Marco Pepe; Rodolfo Gialletti; Benedetta Passeri; Paola Modesto; Alessandro Ghelardi; Katia Cappelli; Elisabetta Razzuoli
Journal:  Biology (Basel)       Date:  2021-03-21
  6 in total

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