Danhong Wu1,2, Xiaoli Yang2, Ping Zhong3, Xiaofei Ye4, Chen Li2, Xueyuan Liu1. 1. Department of Neurology, Shanghai Tenth People's Hospital of Nanjing Medical University, Shanghai, People's Republic of China. 2. Department of Neurology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, People's Republic of China. 3. Shanghai Traditional Chinese and Western Medicine Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China. 4. Department of Health Statistics, The Chinese People's Liberation Navy Medical College, Shanghai, People's Republic of China.
Abstract
OBJECTIVES: To investigate the association between insulin resistance (IR) and enlarged perivascular space (EPVS) in the basal gangliain nondiabetic healthy elderly population. METHODS: A total of 235 nondiabetic healthy elderly population were recruited. A 3-level scale was used to evaluate the burden of EPVSs. The homeostasis model assessment-estimated insulin resistance index (HOMA-IR) was used for IR estimation. Correlation between IR and severity of EPVS was assessed using the regression model after adjusting demographics and cardiovascular risk factors. RESULTS: The top quartile of HOMA-IR was 2.52, and 25.11% of patients showed IR. The proportion of patients with IR was higher in the moderate to severe EPVS group than in the mild group (36.51% vs 20.93%, P = .015). In multivariate logistic analysis, IR was positively correlated with the moderate to severe EPVS (adjusted odds ratio: 3.532, 95% confidence interval: 1.633-7.636, P = .001) after adjusting classical risk factors. CONCLUSIONS: Insulin resistance was independently correlated with EPVS in the basal ganglia in nondiabetic healthy elderly population.
OBJECTIVES: To investigate the association between insulin resistance (IR) and enlarged perivascular space (EPVS) in the basal gangliain nondiabetic healthy elderly population. METHODS: A total of 235 nondiabetic healthy elderly population were recruited. A 3-level scale was used to evaluate the burden of EPVSs. The homeostasis model assessment-estimated insulin resistance index (HOMA-IR) was used for IR estimation. Correlation between IR and severity of EPVS was assessed using the regression model after adjusting demographics and cardiovascular risk factors. RESULTS: The top quartile of HOMA-IR was 2.52, and 25.11% of patients showed IR. The proportion of patients with IR was higher in the moderate to severe EPVS group than in the mild group (36.51% vs 20.93%, P = .015). In multivariate logistic analysis, IR was positively correlated with the moderate to severe EPVS (adjusted odds ratio: 3.532, 95% confidence interval: 1.633-7.636, P = .001) after adjusting classical risk factors. CONCLUSIONS:Insulin resistance was independently correlated with EPVS in the basal ganglia in nondiabetic healthy elderly population.