Cui Guo1, Ta-Chien Chan2, Yung-Chu Teng3, Changqing Lin4, Yacong Bo1, Ly-Yun Chang5, Alexis K H Lau4, Tony Tam6, Martin C S Wong1, Xiang Qian Lao7. 1. Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong Special Administrative Region. 2. Research Center for Humanities and Social Sciences, Academia Sinica, Taiwan; Institute of Public Health, School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address: dachianpig@gmail.com. 3. Research Center for Humanities and Social Sciences, Academia Sinica, Taiwan. 4. Division of Environment and Sustainability, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region; Department of Civil and Environmental Engineering, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region. 5. Institute of Sociology, Academia Sinica, Taiwan; Gratia Christian College, Hong Kong Special Administrative Region. 6. Department of Sociology, The Chinese University of Hong Kong, Hong Kong Special Administrative Region. 7. Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong Special Administrative Region; Shenzhen Research Institute of the Chinese University of Hong Kong, Shenzhen, China. Electronic address: xqlao@cuhk.edu.hk.
Abstract
BACKGROUND: Information on the association between long-term exposure to PM2.5 and gastrointestinal cancer mortality is scarce. OBJECTIVES: This study investigated the association between long-term exposure to PM2.5 and deaths from gastrointestinal cancer and its subtypes in adults in Taiwan. METHODS: A total of 385,650 Taiwanese adults (≥18 years old) jointed a standard medical examination program between 2001 and 2014 and were followed up until 2016. Their vital data were obtained from the National Death Registry maintained by the Ministry of Health and Welfare in Taiwan. We estimated the ambient PM2.5 concentration at individual's address utilising a satellite-based spatiotemporal model at a resolution of 1 km2. Cox proportional hazard regression model was used to investigate the associations between ambient PM2.5 and deaths from gastrointestinal, stomach, colorectal and liver cancers. RESULTS: We found that each 10 µg/m3 increase in PM2.5 was associated with an increased hazard risk (HR) of 1.09 (95% confidence interval (CI): 1.03-1.16) and 1.13 (95%CI: 1.02-1.24) in deaths from gastrointestinal and liver cancers, respectively. The association between PM2.5 and death from colorectal cancer was marginally statistically significant [HR: 1.13 (95%CI: 1.00-1.26)]. We did not find significant associations between PM2.5 and mortality from stomach cancer. CONCLUSIONS: Long-term exposure to ambient PM2.5 was associated with an increased risk of deaths from gastrointestinal cancers, liver cancer and also potentially colorectal cancer. Air pollution control strategies are necessary to reduce the burden of gastrointestinal cancer.
BACKGROUND: Information on the association between long-term exposure to PM2.5 and gastrointestinal cancer mortality is scarce. OBJECTIVES: This study investigated the association between long-term exposure to PM2.5 and deaths from gastrointestinal cancer and its subtypes in adults in Taiwan. METHODS: A total of 385,650 Taiwanese adults (≥18 years old) jointed a standard medical examination program between 2001 and 2014 and were followed up until 2016. Their vital data were obtained from the National Death Registry maintained by the Ministry of Health and Welfare in Taiwan. We estimated the ambient PM2.5 concentration at individual's address utilising a satellite-based spatiotemporal model at a resolution of 1 km2. Cox proportional hazard regression model was used to investigate the associations between ambient PM2.5 and deaths from gastrointestinal, stomach, colorectal and liver cancers. RESULTS: We found that each 10 µg/m3 increase in PM2.5 was associated with an increased hazard risk (HR) of 1.09 (95% confidence interval (CI): 1.03-1.16) and 1.13 (95%CI: 1.02-1.24) in deaths from gastrointestinal and liver cancers, respectively. The association between PM2.5 and death from colorectal cancer was marginally statistically significant [HR: 1.13 (95%CI: 1.00-1.26)]. We did not find significant associations between PM2.5 and mortality from stomach cancer. CONCLUSIONS: Long-term exposure to ambient PM2.5 was associated with an increased risk of deaths from gastrointestinal cancers, liver cancer and also potentially colorectal cancer. Air pollution control strategies are necessary to reduce the burden of gastrointestinal cancer.
Authors: Natalie Pritchett; Emily C Spangler; George M Gray; Alicia A Livinski; Joshua N Sampson; Sanford M Dawsey; Rena R Jones Journal: Environ Health Perspect Date: 2022-03-02 Impact factor: 9.031
Authors: Miyoun Shin; Ok-Jin Kim; Seongwoo Yang; Seung-Ah Choe; Sun-Young Kim Journal: Int J Environ Res Public Health Date: 2022-03-08 Impact factor: 3.390