Liya Teklu Araya1, Teferi Gedif Fenta1, Beate Sander2,3,4,5, Girma Tekle Gebremariam6, Gebremedhin Beedemariam Gebretekle7. 1. Social and Administrative Pharmacy Unit, School of Pharmacy, College of Health Sciences, Addis Ababa University, Zambia Street, P.O. Box: 1176, Addis Ababa, Ethiopia. 2. Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada. 3. Toronto Health Economics and Technology Assessment (THETA) Collaborative, University Health Network, Toronto, Ontario, Canada. 4. ICES, Toronto, Ontario, Canada. 5. Public Health Ontario, Toronto, Ontario, Canada. 6. Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia. 7. Social and Administrative Pharmacy Unit, School of Pharmacy, College of Health Sciences, Addis Ababa University, Zambia Street, P.O. Box: 1176, Addis Ababa, Ethiopia. gebremedhin.beedemariam@aau.edu.et.
Abstract
BACKGROUND: Cancer of the cervix is the most frequent cancer among women in Ethiopia. The disease burden and its treatment adversely affects patients' health-related quality of life (HRQoL). We aimed to investigate the HRQoL and its predictors among cervical cancer patients in Ethiopia. METHODS: A hospital-based cross-sectional study was conducted from January to June 2018 at the oncology unit of Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. A total of 404 cervical cancer patients were interviewed using validated Amharic version of the European Organization for Research and Treatment of Cancer module (EORTC QLQ-C30), cervical cancer module (EORTC QLQ-CX24), and Euro Quality of Life Group's 5-Domain Questionnaires 5-Levels (EQ-5D) questionnaires. ANOVA test was used to determine the effect of patients' characteristics on mean scores of the different domains of HRQoL and stepwise multivariable logistic regression was performed to identify predictors of HRQoL. Coefficients of level-specific utility values obtained from a hybrid regression model for the Ethiopian general population were used to compute utility. RESULTS: The mean age of patients was 52.1 ± 10.4 years and 379 (93.8%) of the patients were receiving service at the outpatient clinic. About one-third (35%) of patients were diagnosed with stage IV cervical cancer. Mean global health status/QoL, mean utility and visual analog scale scores were 48.3 ± 23.77, 0.77 and 65.7 ± 20.83, respectively. Physical functioning (AOR = 4.98, 95% CI:2.16-11.49), emotional functioning (AOR = 5.25, 95% CI:2.26-12.17), pain (AOR = 5.79, 95% CI:2.30-14.57), and symptom experience (AOR = 4.58, 95% CI:1.95-10.79) were associated with patients' HRQoL. CONCLUSIONS: Cervical cancer significantly affects patient's HRQoL and hence, efforts to improve HRQoL should be commenced especially in terms of physical and emotional functioning, pain, and symptom experience.
BACKGROUND:Cancer of the cervix is the most frequent cancer among women in Ethiopia. The disease burden and its treatment adversely affects patients' health-related quality of life (HRQoL). We aimed to investigate the HRQoL and its predictors among cervical cancerpatients in Ethiopia. METHODS: A hospital-based cross-sectional study was conducted from January to June 2018 at the oncology unit of Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. A total of 404 cervical cancerpatients were interviewed using validated Amharic version of the European Organization for Research and Treatment of Cancer module (EORTC QLQ-C30), cervical cancer module (EORTC QLQ-CX24), and Euro Quality of Life Group's 5-Domain Questionnaires 5-Levels (EQ-5D) questionnaires. ANOVA test was used to determine the effect of patients' characteristics on mean scores of the different domains of HRQoL and stepwise multivariable logistic regression was performed to identify predictors of HRQoL. Coefficients of level-specific utility values obtained from a hybrid regression model for the Ethiopian general population were used to compute utility. RESULTS: The mean age of patients was 52.1 ± 10.4 years and 379 (93.8%) of the patients were receiving service at the outpatient clinic. About one-third (35%) of patients were diagnosed with stage IV cervical cancer. Mean global health status/QoL, mean utility and visual analog scale scores were 48.3 ± 23.77, 0.77 and 65.7 ± 20.83, respectively. Physical functioning (AOR = 4.98, 95% CI:2.16-11.49), emotional functioning (AOR = 5.25, 95% CI:2.26-12.17), pain (AOR = 5.79, 95% CI:2.30-14.57), and symptom experience (AOR = 4.58, 95% CI:1.95-10.79) were associated with patients' HRQoL. CONCLUSIONS:Cervical cancer significantly affects patient's HRQoL and hence, efforts to improve HRQoL should be commenced especially in terms of physical and emotional functioning, pain, and symptom experience.
Entities:
Keywords:
Cervical cancer; EQ-5D; Ethiopia; Health-related quality of life; Utility
Authors: Karen Y Chung; Gebremedhin B Gebretekle; Andrew Howard; Eleanor Pullenayegum; Mekonen Eshete; Christopher R Forrest; Beate Sander Journal: JAMA Netw Open Date: 2022-07-01
Authors: Kwabena Amo-Antwi; Ramatu Agambire; Thomas O Konney; Samuel B Nguah; Edward T Dassah; Yvonne Nartey; Adu Appiah-Kubi; Augustine Tawiah; Elliot K Tannor; Amponsah Peprah; Mavis Bobie Ansah; Daniel Sam; Patrick K Akakpo; Frank Ankobea; Rex M Djokoto; Maame Y K Idun; Henry S Opare-Addo; Baafour K Opoku; Alexander T Odoi; Carolyn Johnston Journal: PLoS One Date: 2022-06-03 Impact factor: 3.752