Cicilia Marcella1, Shakeel Sarwar2, Hui Ye1, Rui Hua Shi1. 1. Department of Gastroenterology, Southeast University Affiliated Zhongda Hospital, Nanjing, China. 2. Department of Orthopedics, Southeast University Affiliated Zhongda Hospital, Nanjing, China.
Abstract
Background/Aims: Endoscopic treatment (ET) has been applied for decades to treat subepithelial tumors, including gastrointestinal stromal tumors (GISTs). However, the efficacy of ET remains debatable. In this study, we evaluated the efficacy and safety of ET for GISTs in the upper gastrointestinal tract. Methods: This retrospective single-center study included 97 patients who underwent ET. All patients were enrolled from July 2014 to July 2018. Parameters such as demographics, size, resection margin, complications, pathological features, procedure time, total cost, and follow-up were investigated and analyzed. Results: Our study achieved 100% en bloc resection and 77.42% (72/93) R0 resection. The most common location was the fundus with a mean tumor size of 2.08±1.43 cm. The mean age, procedure time, hospital stay, and cost were 59.65±11.29 years, 64.74±35.23 minutes, 6.82 days, and 5,337 dollars, respectively. According to National Institutes of Health classification, 63 (64.95%), 26 (26.81%), 5 (5.15%), and 3 (3.09%) patients belonged to the very low, low, intermediate, and high risk classification, respectively. Immunohistochemistry results showed a 100% positive rate of CD34, DOG-1, CD117, and Ki67. A mean follow-up of 21.29±12.97 months showed no recurrence or metastasis. Conclusions: ET is effective and safe for curative removal of GISTs in the upper gastrointestinal tract, and it can be a treatment of choice for patients with no metastasis.
Background/Aims: Endoscopic treatment (ET) has been applied for decades to treat subepithelial tumors, including gastrointestinal stromal tumors (GISTs). However, the efficacy of ET remains debatable. In this study, we evaluated the efficacy and safety of ET for GISTs in the upper gastrointestinal tract. Methods: This retrospective single-center study included 97 patients who underwent ET. All patients were enrolled from July 2014 to July 2018. Parameters such as demographics, size, resection margin, complications, pathological features, procedure time, total cost, and follow-up were investigated and analyzed. Results: Our study achieved 100% en bloc resection and 77.42% (72/93) R0 resection. The most common location was the fundus with a mean tumor size of 2.08±1.43 cm. The mean age, procedure time, hospital stay, and cost were 59.65±11.29 years, 64.74±35.23 minutes, 6.82 days, and 5,337 dollars, respectively. According to National Institutes of Health classification, 63 (64.95%), 26 (26.81%), 5 (5.15%), and 3 (3.09%) patients belonged to the very low, low, intermediate, and high risk classification, respectively. Immunohistochemistry results showed a 100% positive rate of CD34, DOG-1, CD117, and Ki67. A mean follow-up of 21.29±12.97 months showed no recurrence or metastasis. Conclusions: ET is effective and safe for curative removal of GISTs in the upper gastrointestinal tract, and it can be a treatment of choice for patients with no metastasis.
Authors: João Santos-Antunes; Margarida Marques; Rui Morais; Francisco Baldaque-Silva; Filipe Vilas-Boas; Pedro Moutinho-Ribeiro; Susana Lopes; Fátima Carneiro; Guilherme Macedo Journal: Ann Gastroenterol Date: 2021-11-10