Meng Xiao1,2,3, Sharon C-A Chen4, Fanrong Kong4, Xiu-Li Xu5, Li Yan6, Hai-Shen Kong7, Xin Fan1,2,3, Xin Hou1,2,3, Jing-Wei Cheng1,2,3, Meng-Lan Zhou1,2,3, Ying Li1,2,3, Shu-Ying Yu1,2,3, Jing-Jing Huang1,2,3, Ge Zhang1,3, Yang Yang1,3, Jing-Jia Zhang1,3, Si-Meng Duan1,3, Wei Kang1,3, He Wang1,3, Ying-Chun Xu1,2,3. 1. Department of Laboratory Medicine, Peking Union Medical College Hospital, Beijing, China. 2. Graduate School, Peking Union Medical College, Beijing, China. 3. Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases, Beijing, China. 4. Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, New South Wales Health Pathology, Westmead Hospital, University of Sydney, Sydney, Australia. 5. Laboratory Department, Xijing Hospital, Air Force Medical University, Xi'an, China. 6. Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 7. Center of Clinical Laboratory, The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, China.
Abstract
BACKGROUND: Candidemia is the most common, serious fungal infection and Candida antifungal resistance is a challenge. We report recent surveillance of candidemia in China. METHODS: The study encompassed 77 Chinese hospitals over 3 years. Identification of Candida species was by mass spectrometry and DNA sequencing. Antifungal susceptibility was determined using the Clinical and Laboratory Standards Institute broth microdilution method. RESULTS: In total, 4010 isolates were collected from candidemia patients. Although C. albicans was the most common species, non-albicans Candida species accounted for over two-thirds of isolates, predominated C. parapsilosis complex (27.1%), C. tropicalis (18.7%), and C. glabrata complex (12.0%). Most C. albicans and C. parapsilosis complex isolates were susceptible to all antifungal agents (resistance rate <5%). However, there was a decrease in voriconazole susceptibility to C. glabrata sensu stricto over the 3 years and fluconazole resistance rate in C. tropicalis tripled. Amongst less common Candida species, over one-third of C. pelliculosa isolates were coresistant to fluconazole and 5-flucytocine, and >56% of C. haemulonii isolates were multidrug resistance. CONCLUSIONS: Non-albicans Candida species are the predominant cause of candidemia in China. Azole resistance is notable amongst C. tropicalis and C. glabrata. Coresistance and multidrug resistance has emerged in less common Candida species.
BACKGROUND:Candidemia is the most common, serious fungal infection and Candida antifungal resistance is a challenge. We report recent surveillance of candidemia in China. METHODS: The study encompassed 77 Chinese hospitals over 3 years. Identification of Candida species was by mass spectrometry and DNA sequencing. Antifungal susceptibility was determined using the Clinical and Laboratory Standards Institute broth microdilution method. RESULTS: In total, 4010 isolates were collected from candidemiapatients. Although C. albicans was the most common species, non-albicans Candida species accounted for over two-thirds of isolates, predominated C. parapsilosis complex (27.1%), C. tropicalis (18.7%), and C. glabrata complex (12.0%). Most C. albicans and C. parapsilosis complex isolates were susceptible to all antifungal agents (resistance rate <5%). However, there was a decrease in voriconazole susceptibility to C. glabrata sensu stricto over the 3 years and fluconazole resistance rate in C. tropicalis tripled. Amongst less common Candida species, over one-third of C. pelliculosa isolates were coresistant to fluconazole and 5-flucytocine, and >56% of C. haemulonii isolates were multidrug resistance. CONCLUSIONS: Non-albicans Candida species are the predominant cause of candidemia in China. Azole resistance is notable amongst C. tropicalis and C. glabrata. Coresistance and multidrug resistance has emerged in less common Candida species.
Authors: D K B Rodrigues; L X Bonfietti; R A Garcia; M R Araujo; J S Rodrigues; V M F Gimenes; M S C Melhem Journal: Braz J Med Biol Res Date: 2021-06-14 Impact factor: 2.590
Authors: Danilo Y Thomaz; João N de Almeida; Odeli N E Sejas; Gilda M B Del Negro; Gabrielle O M H Carvalho; Viviane M F Gimenes; Maria Emilia B de Souza; Amir Arastehfar; Carlos H Camargo; Adriana L Motta; Flávia Rossi; David S Perlin; Maristela P Freire; Edson Abdala; Gil Benard Journal: J Fungi (Basel) Date: 2021-03-30