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Literature DB >> 32174756

Molecular targets and novel therapeutic avenues in soft-tissue sarcoma.

Abstract

Soft-tissue sarcoma (sts) represents a heterogeneous group of rare tumours, and a significant number of affected patients will develop metastatic disease. Outcomes in the population with metastatic disease are generally poor, especially after progression on standard chemotherapy. The advent of personalized medicine has permitted oncologists to offer targeted treatment, thus addressing the limited treatment options and poor prognosis after progression on first-line chemotherapy. In this review, we delineate the existing data and therapeutic successes with respect to existing and emerging molecular targets in sts and options for immunotherapy in sts. Our review also summarizes emerging clinical trials that are currently recruiting patients. 2020 Multimed Inc.

Entities: Disease Species

Keywords: Sarcoma; chemotherapy; immunotherapy; targeted therapy

Mesh：

Year: 2020 PMID： 32174756 PMCID： PMC7050044 DOI： 10.3747/co.27.5631

Source DB: PubMed Journal: Curr Oncol ISSN： 1198-0052 Impact factor: 3.677

48 in total

1. Sorafenib for Advanced and Refractory Desmoid Tumors.

Authors: Mrinal M Gounder; Michelle R Mahoney; Brian A Van Tine; Vinod Ravi; Steven Attia; Hari A Deshpande; Abha A Gupta; Mohammed M Milhem; Robert M Conry; Sujana Movva; Michael J Pishvaian; Richard F Riedel; Tarek Sabagh; William D Tap; Natally Horvat; Ethan Basch; Lawrence H Schwartz; Robert G Maki; Narasimhan P Agaram; Robert A Lefkowitz; Yousef Mazaheri; Rikiya Yamashita; John J Wright; Amylou C Dueck; Gary K Schwartz
Journal: N Engl J Med Date: 2018-12-20 Impact factor: 91.245

2. Phase II trial of weekly paclitaxel for unresectable angiosarcoma: the ANGIOTAX Study.

Authors: Nicolas Penel; Binh Nguyen Bui; Jacques-Olivier Bay; Didier Cupissol; Isabelle Ray-Coquard; Sophie Piperno-Neumann; Pierre Kerbrat; Charles Fournier; Sophie Taieb; Marta Jimenez; Nicolas Isambert; Frédéric Peyrade; Christine Chevreau; Emmanuelle Bompas; Etienne G C Brain; Jean-Yves Blay
Journal: J Clin Oncol Date: 2008-09-22 Impact factor: 44.544

3. Treatment of Desmoid Tumors in 2019.

Authors: Alessandro Gronchi; Robin L Jones
Journal: JAMA Oncol Date: 2019-04-01 Impact factor: 31.777

4. Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children.

Authors: Alexander Drilon; Theodore W Laetsch; Shivaani Kummar; Steven G DuBois; Ulrik N Lassen; George D Demetri; Michael Nathenson; Robert C Doebele; Anna F Farago; Alberto S Pappo; Brian Turpin; Afshin Dowlati; Marcia S Brose; Leo Mascarenhas; Noah Federman; Jordan Berlin; Wafik S El-Deiry; Christina Baik; John Deeken; Valentina Boni; Ramamoorthy Nagasubramanian; Matthew Taylor; Erin R Rudzinski; Funda Meric-Bernstam; Davendra P S Sohal; Patrick C Ma; Luis E Raez; Jaclyn F Hechtman; Ryma Benayed; Marc Ladanyi; Brian B Tuch; Kevin Ebata; Scott Cruickshank; Nora C Ku; Michael C Cox; Douglas S Hawkins; David S Hong; David M Hyman
Journal: N Engl J Med Date: 2018-02-22 Impact factor: 91.245

5. Targetable Alterations in Adult Patients With Soft-Tissue Sarcomas: Insights for Personalized Therapy.

Authors: Carlo Lucchesi; Emmanuel Khalifa; Yec'han Laizet; Isabelle Soubeyran; Simone Mathoulin-Pelissier; Christine Chomienne; Antoine Italiano
Journal: JAMA Oncol Date: 2018-10-01 Impact factor: 31.777

6. Paclitaxel and pegylated-liposomal doxorubicin are both active in angiosarcoma.

Authors: Keith M Skubitz; Philip A Haddad
Journal: Cancer Date: 2005-07-15 Impact factor: 6.860

7. Long-term Efficacy of Methotrexate Plus Vinblastine/Vinorelbine in a Large Series of Patients Affected by Desmoid-Type Fibromatosis.

Authors: Elena Palassini; Anna Maria Frezza; Luigi Mariani; Luca Lalli; Chiara Colombo; Marco Fiore; Antonella Messina; Alessandra Casale; Carlo Morosi; Paola Collini; Silvia Stacchiotti; Paolo Giovanni Casali; Alessandro Gronchi
Journal: Cancer J Date: 2017 Mar/Apr Impact factor: 3.360

Review 8. Diffuse-type tenosynovial giant cell tumour: Current treatment concepts and future perspectives.

Authors: Eric L Staals; Stefano Ferrari; Davide M Donati; Emanuela Palmerini
Journal: Eur J Cancer Date: 2016-06-05 Impact factor: 9.162

9. Hormonal manipulation with toremifene in sporadic desmoid-type fibromatosis.

Authors: Marco Fiore; Chiara Colombo; Stefano Radaelli; Dario Callegaro; Elena Palassini; Marta Barisella; Carlo Morosi; Giacomo G Baldi; Silvia Stacchiotti; Paolo G Casali; Alessandro Gronchi
Journal: Eur J Cancer Date: 2015-11-18 Impact factor: 9.162

Review 10. An update on the management of sporadic desmoid-type fibromatosis: a European Consensus Initiative between Sarcoma PAtients EuroNet (SPAEN) and European Organization for Research and Treatment of Cancer (EORTC)/Soft Tissue and Bone Sarcoma Group (STBSG).

Authors: B Kasper; C Baumgarten; J Garcia; S Bonvalot; R Haas; F Haller; P Hohenberger; N Penel; C Messiou; W T van der Graaf; A Gronchi
Journal: Ann Oncol Date: 2017-10-01 Impact factor: 32.976

3 in total

1. Efficacy and Safety of Apatinib Treatment for Patients with Advanced Intrahepatic Cholangiocarcinoma.

Authors: Guohe Lin; Bicheng Wang; Xiuwei Wu; Tong Sun; Lili Chen; Canliang Lu; Nianfei Wang
Journal: Cancer Manag Res Date: 2020-11-10 Impact factor: 3.989

Review 2. The Sarcoma Immune Landscape: Emerging Challenges, Prognostic Significance and Prospective Impact for Immunotherapy Approaches.

Authors: Anna Koumarianou; Jose Duran-Moreno
Journal: Cancers (Basel) Date: 2021-01-20 Impact factor: 6.639

Review 3. Prospects for Epigenetic Targeted Therapies of Bone and Soft-Tissue Sarcomas.

Authors: Jun Wang; Arielle Elkrief; Wei Guo; Neerav Shukla; Mrinal Gounder; Marc Ladanyi
Journal: Sarcoma Date: 2021-07-26

3 in total