Literature DB >> 32173735

Protective effects of new aryl sulfone derivatives against radiation-induced hematopoietic injury.

Jian Cao1, Hongyan Li1, Renbin Yuan1, Yinping Dong1, Jing Wu1, Meifang Wang1, Deguan Li1, Hongqi Tian1, Hui Dong1.   

Abstract

The hematopoietic system is sensitive to radiation. In this research, new aryl sulfone derivatives (XH-201 and XH-202) containing a nitrogen heterocycle were designed and synthesized and their radio-protective efficacies with regard to the hematopoietic system were evaluated. XH-201 administration significantly increased the survival rate of mice after 8.0 Gy total body irradiation (TBI). The results showed that XH-201 treatment not only increased the white blood cells, platelets counts and the percentage of hematopoietic progenitor cells and hematopoietic stem cells in mice exposed to 4.0 Gy TBI but also decreased DNA damage, as determined by flow cytometric analysis of histone H2AX phosphorylation. In addition, our data demonstrated that XH-201 decreased the mitochondrial reactive oxygen species (ROS) levels in hematopoietic cells. Overall, these data suggest that XH-201 is beneficial for the protection of the hemoatopoietic system against radiation-induced injuries.
© The Author(s) 2020. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology.

Entities:  

Keywords:  aryl sulfone derivatives; hematopoietic cells; radioprotection

Mesh：

Substances：

Year:  2020        PMID： 32173735      PMCID： PMC7299261          DOI： 10.1093/jrr/rraa009

Source DB:  PubMed          Journal:  J Radiat Res        ISSN： 0449-3060            Impact factor:   2.724


  40 in total

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