Marco Danova1, Andrea Antonuzzo2, Federico Spandonaro3, Paolo Pronzato4. 1. Department of Internal Medicine and Oncology, ASST di Pavia, Pavia, Italy. 2. Medical Oncology 1, Polo Oncologico, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy. 3. Tor Vergata University of Rome, Rome, and Consortium for Applied Economic Research in the Heath Sector (CREA Sanitá), Rome, Italy. 4. Medical Oncology, IRCCS Azienda Ospedaliero, Universitaria San Martino, IST, Genova, Italy.