Literature DB >> 32172208

The relationship between TIGIT+ regulatory T cells and autoimmune disease.

Darren J Lee1.   

Abstract

The role of regulatory T cells (Treg cell) in controlling autoimmune disease is an area of intense study. As such, the characterization and understanding the function of Treg markers has the potential to provide a considerable impact in developing treatments and understanding the pathogenesis of autoimmune diseases. One such inhibitory Treg cell marker that has been recently discovered is T cell immunoglobulin and ITIM domain (TIGIT). In this review, we discuss what is known about the expression and function of TIGIT on Treg cells, and we discuss the relationship between TIGIT expressing Treg cells and different autoimmune diseases such as atopic dermatitis, autoimmune thyroiditis, type 1 diabetes, autoimmune uveitis, aplastic anemia, multiple sclerosis, systemic lupus erythematosus, arthritis, and colitis.
Copyright © 2020 Elsevier B.V. All rights reserved.

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Year:  2020        PMID： 32172208      PMCID： PMC7250710          DOI： 10.1016/j.intimp.2020.106378

Source DB:  PubMed          Journal:  Int Immunopharmacol        ISSN： 1567-5769            Impact factor:   4.932


  60 in total

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Journal:  JCI Insight       Date:  2019-02-07

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10.  Phenotypic Complexity of the Human Regulatory T Cell Compartment Revealed by Mass Cytometry.

Authors:  Gavin M Mason; Katie Lowe; Rossella Melchiotti; Richard Ellis; Emanuele de Rinaldis; Mark Peakman; Susanne Heck; Giovanna Lombardi; Timothy I M Tree
Journal:  J Immunol       Date:  2015-07-29       Impact factor: 5.422
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2.  Downregulation of TIGIT Expression in FOXP3+Regulatory T Cells in Acute Coronary Syndrome.

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Journal:  J Inflamm Res       Date:  2022-02-22

3.  Pruritus, Allergy and Autoimmunity: Paving the Way for an Integrated Understanding of Psychodermatological Diseases?

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  3 in total

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