| Literature DB >> 32171562 |
Russell E Ware1, Anu Marahatta2, Julie L Ware3, Kathryn McElhinney2, Min Dong4, Alexander A Vinks4.
Abstract
Lactation is contraindicated for women with sickle cell anemia receiving hydroxyurea therapy, despite sparse pharmacokinetics data. In 16 women who were lactating volunteers, we documented hydroxyurea transferred into breastmilk with a relative infant dosage of 3.4%, which is below the recommended 5%-10% safety threshold. Breastfeeding should be permitted for women taking daily oral hydroxyurea.Entities:
Keywords: breastfeeding; hydroxyurea; pharmacokinetics; sickle cell anemia
Year: 2020 PMID： 32171562 DOI： 10.1016/j.jpeds.2020.02.002
Source DB: PubMed Journal: J Pediatr ISSN： 0022-3476 Impact factor: 4.406