Andreia Araújo Porchat Leão1, Camilla Kapp Fritz2, Marcia Regina Messaggi Gomes Dias3, Julienne Angela Ramires Carvalho4, Luis Paulo Gomes Mascarenhas5, Mônica Nunes Lima Cat4, Rosana Radominski6, Suzana Nesi-França7. 1. Postgraduate Program in Child and Adolescent Health, Department of Pediatrics, Federal University of Paraná, Curitiba, Paraná, Brazil. Electronic address: andreia_leao@hotmail.com. 2. Postgraduate Program in Child and Adolescent Health, Department of Pediatrics, Federal University of Paraná, Curitiba, Paraná, Brazil. 3. School of Nutrition, Federal University of Paraná, Curitiba, Paraná, Brazil. 4. Department of Pediatrics, School of Medicine, Federal University of Paraná, Curitiba, Paraná, Brazil. 5. School of Physical Education, State University of Midwest, Irati, Paraná, Brazil. 6. Postgraduate Program in Food and Nutrition, Federal University of Paraná, Curitiba, Paraná, Brazil. 7. Department of Pediatrics, Federal University of Paraná, Curitiba, Paraná, Brazil.
Abstract
OBJECTIVES: To evaluate the bone mineral density (BMD) in children/adolescents with type 1 diabetes mellitus (T1DM) and its association with the nutritional intake, metabolic control, and physical activity level of this population. METHODS: Study including 34 patients with T1DM and 17 controls. Assessments included the participants disease history, intake of macronutrient, calcium, phosphorus and magnesium, physical activity level, total body and lumbar spine BMD and serum levels of glycated hemoglobin, vitamin D, calcium, phosphorus, magnesium, osteocalcin and C-terminal telopeptide. RESULTS: Total body and lumbar spine BMD z-scores were normal in all but two participants in the T1DM group. The T1DM group had significantly lower total body BMD z-score values (p < 0.001) and levels of osteocalcin, C-terminal telopeptide, calcium, phosphorus, and magnesium. Intake of macronutrients and calcium was inadequate in both groups. Participants in the T1DM group were more sedentary (88%) and had inadequate metabolic control (91%) and low vitamin D levels (82%). Bone mass in the T1DM group was influenced by body mass index (BMI), pubertal stage, disease duration, calcium intake, and physical activity level. CONCLUSIONS: Bone mass in patients with T1DM was adequate but lower than controls and was influenced by BMI, pubertal stage, disease duration, calcium consumption, and physical activity level.
OBJECTIVES: To evaluate the bone mineral density (BMD) in children/adolescents with type 1 diabetes mellitus (T1DM) and its association with the nutritional intake, metabolic control, and physical activity level of this population. METHODS: Study including 34 patients with T1DM and 17 controls. Assessments included the participants disease history, intake of macronutrient, calcium, phosphorus and magnesium, physical activity level, total body and lumbar spine BMD and serum levels of glycated hemoglobin, vitamin D, calcium, phosphorus, magnesium, osteocalcin and C-terminal telopeptide. RESULTS: Total body and lumbar spine BMD z-scores were normal in all but two participants in the T1DM group. The T1DM group had significantly lower total body BMD z-score values (p < 0.001) and levels of osteocalcin, C-terminal telopeptide, calcium, phosphorus, and magnesium. Intake of macronutrients and calcium was inadequate in both groups. Participants in the T1DM group were more sedentary (88%) and had inadequate metabolic control (91%) and low vitamin D levels (82%). Bone mass in the T1DM group was influenced by body mass index (BMI), pubertal stage, disease duration, calcium intake, and physical activity level. CONCLUSIONS: Bone mass in patients with T1DM was adequate but lower than controls and was influenced by BMI, pubertal stage, disease duration, calcium consumption, and physical activity level.
Authors: Roman Rahmani; Elizabeth Stevens; Noya Rackovsky; Kimberly O O'Brien; George J Schwartz; David R Weber Journal: Front Clin Diabetes Healthc Date: 2021-09-06