Jah Yeon Choi1, Byoung Geol Choi2, Seung-Woon Rha1, Ahmed Mashaly1, Kareem Abdelshafi1, Cheol Ung Choi1, Cheol Woong Yu3, Hyeon-Cheol Gwon4, In-Ho Chae5, Hyo-Soo Kim5, Hun Sik Park6, Seung-Hwan Lee7, Moo-Hyun Kim8, Seung-Ho Hur9, Yangsoo Jang10. 1. Cardiovascular Center, Korea University Guro Hospital. 2. Department of Medicine, Korea University Graduate School. 3. Cardiovascular Center, Korea University Anam Hospital, Seoul, Korea, Republic of Korea. 4. Samsung Medical Center, Sungkyunkwan University School of Medicine. 5. Seoul National University Hospital, Seoul. 6. Kyungpook National University Hospital, Daegu. 7. Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Seoul. 8. Dong-A University Hospital, Busan. 9. Keimyung University Dongsan Medical Center, Daegu. 10. Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Abstract
BACKGROUND: Chronic total occlusion intervention remains challenging and detailed real-world data on the safety and efficacy of which are limited. This study sought to determine whether there are differences in the 1-year clinical outcomes between chronic total occlusion patients with acute coronary syndrome and stable angina following chronic total occlusion intervention. PATIENTS AND METHODS: Data from the Korean chronic total occlusion registry were collected from May 2003 to September 2012, and a total of 3268 patients who underwent chronic total occlusion intervention were enrolled. Cardiovascular outcomes up to 12 months in the acute coronary syndrome group were compared with stable angina group. RESULTS: The acute coronary syndrome group consisted of 1657 patients, and stable angina group consisted of 1264 patients. In the acute coronary syndrome group, patients with successful chronic total occlusion intervention had a lower incidence of total death and cardiac death compared to patients with failed intervention. However, there were no significant differences in cardiovascular events in the stable angina group. The successful chronic total occlusion intervention was a significant prognostic factor for lower total death (P = 0.006, hazard ratio = 0.46) and cardiac death (P = 0.003, hazard ratio = 0.36) within acute coronary syndrome group. On the other hand, successful chronic total occlusion intervention was not a prognostic factor for cardiovascular events within stable angina group. CONCLUSIONS: Successful chronic total occlusion intervention in acute coronary syndrome patients was associated with a lower incidence of cardiovascular outcome compared to patients with failed chronic total occlusion intervention.
BACKGROUND: Chronic total occlusion intervention remains challenging and detailed real-world data on the safety and efficacy of which are limited. This study sought to determine whether there are differences in the 1-year clinical outcomes between chronic total occlusion patients with acute coronary syndrome and stable angina following chronic total occlusion intervention. PATIENTS AND METHODS: Data from the Korean chronic total occlusion registry were collected from May 2003 to September 2012, and a total of 3268 patients who underwent chronic total occlusion intervention were enrolled. Cardiovascular outcomes up to 12 months in the acute coronary syndrome group were compared with stable angina group. RESULTS: The acute coronary syndrome group consisted of 1657 patients, and stable angina group consisted of 1264 patients. In the acute coronary syndrome group, patients with successful chronic total occlusion intervention had a lower incidence of total death and cardiac death compared to patients with failed intervention. However, there were no significant differences in cardiovascular events in the stable angina group. The successful chronic total occlusion intervention was a significant prognostic factor for lower total death (P = 0.006, hazard ratio = 0.46) and cardiac death (P = 0.003, hazard ratio = 0.36) within acute coronary syndrome group. On the other hand, successful chronic total occlusion intervention was not a prognostic factor for cardiovascular events within stable angina group. CONCLUSIONS: Successful chronic total occlusion intervention in acute coronary syndromepatients was associated with a lower incidence of cardiovascular outcome compared to patients with failed chronic total occlusion intervention.
Authors: Luyan Zhang; Yaling Tian; Hong Ren; Aihong Zhu; Li Dong; Xiuqin Wang; Xiaoyu Han Journal: Comput Math Methods Med Date: 2022-07-21 Impact factor: 2.809