Rohan V Navani1, Arul Baradi2, Kuo Lin Colin Huang3, David Jin2, Yuxin Jiao4, Jacqueline K Nguyen3, Zachary C Ellis3, Andrew E Newcomb5, Andrew M Wilson2. 1. Melbourne Medical School, The University of Melbourne, Melbourne, Australia; Department of Cardiology, St Vincent's Hospital, Melbourne, Australia. Electronic address: rohan.navani@gmail.com. 2. Department of Cardiology, St Vincent's Hospital, Melbourne, Australia. 3. Melbourne Medical School, The University of Melbourne, Melbourne, Australia; Department of Cardiology, St Vincent's Hospital, Melbourne, Australia. 4. Melbourne Medical School, The University of Melbourne, Melbourne, Australia. 5. Department of Cardiothoracic Surgery, St Vincent's Hospital, Melbourne, Australia.
Abstract
BACKGROUND: Postoperative atrial fibrillation (POAF) is a common complication following coronary artery bypass graft surgery (CABG) and is associated with increased short and long-term mortality. While the precise etiology of POAF remains unclear, inflammation is a known contributing factor. Preliminary studies have suggested that an elevated preoperative platelet-to-lymphocyte ratio (PLR), an inexpensive and readily available novel inflammatory biomarker, may be associated with increased incidence of POAF following CABG. This study sought to further investigate this hypothesis. METHODS: The study cohort included all patients undergoing isolated CABG, with no prior history of arrhythmia, who were operated on between August 1, 2010 and December 31, 2018 at a major Australian tertiary center (n=1,457). Patients were divided into the 'low' (<86) or 'high' (≥86) PLR group based on an optimal cut-off derived from receiver operating curve analysis. The incidence of POAF was then compared. Categorical variables were analyzed using the chi-squared test and continuous variables using logistic regression. RESULTS: Of 1,457 patients, 495 (34.0%) developed POAF. There was no statistically significant difference in the incidence of POAF between patients in the high and low PLR groups (34.8% vs 31.0%, p=0.22). Using multivariable logistic regression analysis, high PLR was not independently associated with POAF (OR 1.04, p=0.78). CONCLUSIONS: Elevated preoperative PLR is not independently associated with POAF in patients undergoing isolated CABG. The findings of this study differ from those of two previous smaller studies.
BACKGROUND:Postoperative atrial fibrillation (POAF) is a common complication following coronary artery bypass graft surgery (CABG) and is associated with increased short and long-term mortality. While the precise etiology of POAF remains unclear, inflammation is a known contributing factor. Preliminary studies have suggested that an elevated preoperative platelet-to-lymphocyte ratio (PLR), an inexpensive and readily available novel inflammatory biomarker, may be associated with increased incidence of POAF following CABG. This study sought to further investigate this hypothesis. METHODS: The study cohort included all patients undergoing isolated CABG, with no prior history of arrhythmia, who were operated on between August 1, 2010 and December 31, 2018 at a major Australian tertiary center (n=1,457). Patients were divided into the 'low' (<86) or 'high' (≥86) PLR group based on an optimal cut-off derived from receiver operating curve analysis. The incidence of POAF was then compared. Categorical variables were analyzed using the chi-squared test and continuous variables using logistic regression. RESULTS: Of 1,457 patients, 495 (34.0%) developed POAF. There was no statistically significant difference in the incidence of POAF between patients in the high and low PLR groups (34.8% vs 31.0%, p=0.22). Using multivariable logistic regression analysis, high PLR was not independently associated with POAF (OR 1.04, p=0.78). CONCLUSIONS: Elevated preoperative PLR is not independently associated with POAF in patients undergoing isolated CABG. The findings of this study differ from those of two previous smaller studies.
Authors: Tomasz Urbanowicz; Anna Olasińska-Wiśniewska; Michał Michalak; Michał Rodzki; Anna Witkowska; Ewa Straburzyńska-Migaj; Bartłomiej Perek; Marek Jemielity Journal: Biology (Basel) Date: 2021-12-27