Bertrand Mathon1, Alice Bordes2, Aymeric Amelot2, Alexandre Carpentier3, Marie Méré4, Sophie Dupont5, Séverine Samson6. 1. AP-HP, La Pitié-Salpêtrière - Charles Foix University Hospital, Department of Neurosurgery, F-75013 Paris, France; Sorbonne University, UPMC Univ. Paris 06, F-75005 Paris, France; Brain and Spine Institute (ICM; INSERM, UMRS 1127; CNRS, UMR 7225), Paris, France. Electronic address: bertrand.mathon@aphp.fr. 2. AP-HP, La Pitié-Salpêtrière - Charles Foix University Hospital, Department of Neurosurgery, F-75013 Paris, France; Sorbonne University, UPMC Univ. Paris 06, F-75005 Paris, France. 3. AP-HP, La Pitié-Salpêtrière - Charles Foix University Hospital, Department of Neurosurgery, F-75013 Paris, France; Sorbonne University, UPMC Univ. Paris 06, F-75005 Paris, France; Brain and Spine Institute (ICM; INSERM, UMRS 1127; CNRS, UMR 7225), Paris, France. 4. AP-HP, La Pitié-Salpêtrière - Charles Foix University Hospital, Epileptology Unit, F-75013 Paris, France. 5. Sorbonne University, UPMC Univ. Paris 06, F-75005 Paris, France; Brain and Spine Institute (ICM; INSERM, UMRS 1127; CNRS, UMR 7225), Paris, France; AP-HP, La Pitié-Salpêtrière - Charles Foix University Hospital, Epileptology Unit, F-75013 Paris, France; AP-HP, La Pitié-Salpêtrière - Charles Foix University Hospital, Rehabilitation Unit, Paris, France. 6. AP-HP, La Pitié-Salpêtrière - Charles Foix University Hospital, Epileptology Unit, F-75013 Paris, France; PSITEC Laboratory (EA 4072), University of Lille, Villeneuve d'Ascq, France.
Abstract
PURPOSE: This study aimed to describe and analyze psychomotor functions in patients with drug-resistant epilepsy and identify factors associated with psychomotor deficits. METHODS: We performed a prospective case-control study comparing psychomotor skill performances in 40 adult patients and 80 healthy individuals between October 2017 and March 2018. Psychomotor functions were examined in both patients and controls using a full set of specific tests (Rey-Osterrieth complex figure test, Zazzo's cancelation task, Piaget-Head test, and paired images test). Potential risk factors for psychomotor deficit were assessed in the patient group using a multivariate analysis. RESULTS: The two groups did not differ in age, sex, dominant hand, and level of education. Compared with the control group, patients with drug-resistant epilepsy showed worse performance on global psychomotor functions and, more selectively, in assessments exploring perceptual organization and visuospatial memory, laterality awareness, sustained attention, concentration, visual scanning, inhibition, and impulsivity. In the patient group, psychomotor deficits were associated with the severity of epilepsy (epileptic encephalopathy, high seizure frequency, heavy antiepileptic medication). CONCLUSION: Psychomotor deficits could therefore be systematically detected in patients with drug-resistant epilepsy in order to provide psychomotor therapy and improve quality of life.
PURPOSE: This study aimed to describe and analyze psychomotor functions in patients with drug-resistant epilepsy and identify factors associated with psychomotor deficits. METHODS: We performed a prospective case-control study comparing psychomotor skill performances in 40 adult patients and 80 healthy individuals between October 2017 and March 2018. Psychomotor functions were examined in both patients and controls using a full set of specific tests (Rey-Osterrieth complex figure test, Zazzo's cancelation task, Piaget-Head test, and paired images test). Potential risk factors for psychomotor deficit were assessed in the patient group using a multivariate analysis. RESULTS: The two groups did not differ in age, sex, dominant hand, and level of education. Compared with the control group, patients with drug-resistant epilepsy showed worse performance on global psychomotor functions and, more selectively, in assessments exploring perceptual organization and visuospatial memory, laterality awareness, sustained attention, concentration, visual scanning, inhibition, and impulsivity. In the patient group, psychomotor deficits were associated with the severity of epilepsy (epilepticencephalopathy, high seizure frequency, heavy antiepileptic medication). CONCLUSION:Psychomotor deficits could therefore be systematically detected in patients with drug-resistant epilepsy in order to provide psychomotor therapy and improve quality of life.