| Literature DB >> 32163673 |
Claudia Torresi1, Mariangela Fiori2, Luigi Bertolotti3, Matteo Floris4, Barbara Colitti3, Monica Giammarioli1, Silvia Dei Giudici2, Annalisa Oggiano2, Maja Malmberg5, Gian Mario De Mia1, Sándor Belák5, Fredrik Granberg5.
Abstract
African swine fever (ASF) is a highly contagious and lethal viral disease of pigs and wild boars, which is enzootic in many African countries and on the Italian island of Sardinia, where it has been present since 1978. Previous genetic analyses of Sardinian ASF virus (ASFV) isolates have revealed that they all belong to p72 genotype I, with only minor sequence variations. However, these studies examined only a few selected genes. To distinguish between these closely related isolates and better investigate ASFV evolution in Sardinia, we sequenced the complete genomes of 12 Sardinian ASFV isolates collected between 1978 and 2012, and compared them with 47/Ss/2008 and 26544/OG10. Most of the observed changes occurred in a time-dependent manner; however, their biological significance remains unclear. As a whole, our results demonstrate the remarkable genetic stability of these strains, supporting a single-source introduction of the virus.Entities:
Keywords: African swine fever virus; Sardinia; comparative genomics; next-generation sequencing
Year: 2020 PMID： 32163673 DOI： 10.1111/tbed.13540
Source DB: PubMed Journal: Transbound Emerg Dis ISSN： 1865-1674 Impact factor: 5.005