Natiele Camponogara Righi1, Felipe Barreto Schuch1,2, Angélica Trevisan De Nardi3, Caroline Montagner Pippi1, Geovana de Almeida Righi1, Gustavo Orione Puntel1, Antonio Marcos Vargas da Silva1, Luis Ulisses Signori4. 1. Department of Physiotherapy and Rehabilitation, Postgraduate Program in Functional Rehabilitation, Federal University of Santa Maria-UFSM, Av. Roraima nº 1000, Cidade Universitária, Bairro Camobi, Santa Maria, RS, 97105-900, Brazil. 2. Department of Sports Methods and Techniques, Federal University of Santa Maria, Santa Maria, RS, Brazil. 3. Exercise Pathophysiology Laboratory, Postgraduate Program in Cardiology and Cardiovascular Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. 4. Department of Physiotherapy and Rehabilitation, Postgraduate Program in Functional Rehabilitation, Federal University of Santa Maria-UFSM, Av. Roraima nº 1000, Cidade Universitária, Bairro Camobi, Santa Maria, RS, 97105-900, Brazil. l.signori@hotmail.com.
Abstract
BACKGROUND: Vitamin C (ascorbic acid) seems to attenuate the overproduction of reactive species during and after exercises. Yet, no meta-analysis has summarized the magnitude of this effect. The objective of this study was to systematically review the effects of vitamin C supplementation on oxidative stress, inflammatory markers, damage, soreness, and the musculoskeletal functionality after a single bout of exercise. METHODS: Major electronic databases were searched, from inception to September 2019, for placebo-controlled randomized clinical trials (RCTs) that evaluated the effects of vitamin C supplementation on oxidative stress parameters, inflammation markers, muscle damage, muscle soreness, and muscle functionality after a single bout of exercise in healthy volunteers. Random-effects modelling was used to compare mean changes from pre- to postexercise in participants that were supplemented with vitamin C versus placebo. Data were reported as standard mean difference (SMD) and 95% confidence interval (CI). RESULTS: A total of 18 RCTs, accounting for 313 participants (62% males, median age = 24 years) were included. Vitamin C supplementation reduced lipid peroxidation immediately (SMD = - 0.488; 95% CI = - 0.888 to - 0.088), 1 h (SMD = - 0.521; 95% CI = - 0.911 to - 0.131) and between 1 and 2 h (SMD = - 0.449; 95% CI = - 0.772 to - 0.126) following exercise. Exercise induced interleukin-6 (IL-6) response was attenuated 2 h (SMD = - 0.764; 95% CI = - 1.279 to - 0.248) and between 1 and 2 h (SMD = - 0.447; 95% CI = - 0.828 to - 0.065) after exercise. No effects of vitamin C supplementation were found on creatine kinase (CK), C-reactive protein (CRP), cortisol levels, muscle soreness, and muscle strength. CONCLUSION: Vitamin C supplementation attenuates the oxidative stress (lipid peroxidation) and inflammatory response (IL-6) to a single bout of exercise. REGISTRATION: PROSPERO (CRD42018094222).
BACKGROUND: Vitamin C (ascorbic acid) seems to attenuate the overproduction of reactive species during and after exercises. Yet, no meta-analysis has summarized the magnitude of this effect. The objective of this study was to systematically review the effects of vitamin C supplementation on oxidative stress, inflammatory markers, damage, soreness, and the musculoskeletal functionality after a single bout of exercise. METHODS: Major electronic databases were searched, from inception to September 2019, for placebo-controlled randomized clinical trials (RCTs) that evaluated the effects of vitamin C supplementation on oxidative stress parameters, inflammation markers, muscle damage, muscle soreness, and muscle functionality after a single bout of exercise in healthy volunteers. Random-effects modelling was used to compare mean changes from pre- to postexercise in participants that were supplemented with vitamin C versus placebo. Data were reported as standard mean difference (SMD) and 95% confidence interval (CI). RESULTS: A total of 18 RCTs, accounting for 313 participants (62% males, median age = 24 years) were included. Vitamin C supplementation reduced lipid peroxidation immediately (SMD = - 0.488; 95% CI = - 0.888 to - 0.088), 1 h (SMD = - 0.521; 95% CI = - 0.911 to - 0.131) and between 1 and 2 h (SMD = - 0.449; 95% CI = - 0.772 to - 0.126) following exercise. Exercise induced interleukin-6 (IL-6) response was attenuated 2 h (SMD = - 0.764; 95% CI = - 1.279 to - 0.248) and between 1 and 2 h (SMD = - 0.447; 95% CI = - 0.828 to - 0.065) after exercise. No effects of vitamin C supplementation were found on creatine kinase (CK), C-reactive protein (CRP), cortisol levels, muscle soreness, and muscle strength. CONCLUSION: Vitamin C supplementation attenuates the oxidative stress (lipid peroxidation) and inflammatory response (IL-6) to a single bout of exercise. REGISTRATION: PROSPERO (CRD42018094222).
Authors: Ilkka Heinonen; Kari K Kalliokoski; Jarna C Hannukainen; Dirk J Duncker; Pirjo Nuutila; Juhani Knuuti Journal: Physiology (Bethesda) Date: 2014-11
Authors: Meir Magal; Charles L Dumke; Zea G Urbiztondo; Michael J Cavill; N Travis Triplett; John C Quindry; Jeff M McBride; Yoram Epstein Journal: J Sports Sci Date: 2010-02 Impact factor: 3.337
Authors: Felipe B Schuch; Brendon Stubbs; Jacob Meyer; Andreas Heissel; Philipp Zech; Davy Vancampfort; Simon Rosenbaum; Jeroen Deenik; Joseph Firth; Philip B Ward; Andre F Carvalho; Sarah A Hiles Journal: Depress Anxiety Date: 2019-06-17 Impact factor: 6.505
Authors: Felipe B Schuch; Davy Vancampfort; Joseph Firth; Simon Rosenbaum; Philip B Ward; Edson S Silva; Mats Hallgren; Antonio Ponce De Leon; Andrea L Dunn; Andrea C Deslandes; Marcelo P Fleck; Andre F Carvalho; Brendon Stubbs Journal: Am J Psychiatry Date: 2018-04-25 Impact factor: 18.112