| Literature DB >> 32162036 |
Pengcheng Zhang1,2,3, Bing Liu4,5.
Abstract
Previous researches exploring associations between multiple myeloma (MM) and genetic polymorphisms showed controversial results. In this investigation, we aimed to make a meta-analysis to assess the association between MM risk and genetic polymorphisms. We searched for articles on genetic polymorphism and MM risk in Web of Science and PubMed databases from 1951 to August 2019. We computed the odds ratio (OR) and 95% confidence intervals (CI) extracted from included articles. The meta-analysis showed no significant associations between MM risks and tumor necrosis factor (TNF)-α (rs1800629/rs361525/rs1799724), interleukin (IL)-6 (rs1800795), multidrug resistance 1 (MDR1) (rs1045642), Methylenetetrahydrofolate reductase (MTHFR) (rs1801131/rs1801133) polymorphisms. In summary, the study shows that the TNF-α (rs1800629/rs361525/rs1799724), IL-6 (rs1800795), MDR1 (rs1045642), and MTHFR (rs1801131/rs1801133) polymorphisms may not be associated with MM susceptibility. Thus, we do not need more expensive and useless studies to explore the associations between MM risks and these genetic polymorphisms.Entities:
Keywords: Interleukin-6; Methylenetetrahydrofolate reductase; Multidrug resistance 1; Multiple myeloma; Tumor necrosis factor-α
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Year: 2020 PMID： 32162036 DOI： 10.1007/s00277-020-03979-7
Source DB: PubMed Journal: Ann Hematol ISSN： 0939-5555 Impact factor: 3.673