| Literature DB >> 32161587 |
Marco Orecchioni1, Yanal Ghosheh1, Akula Bala Pramod1, Klaus Ley1,2.
Abstract
[This corrects the article DOI: 10.3389/fimmu.2019.01084.].Entities:
Keywords: M1; M2; cancer; innate immunity; macrophage
Year: 2020 PMID: 32161587 PMCID: PMC7053374 DOI: 10.3389/fimmu.2020.00234
Source DB: PubMed Journal: Front Immunol ISSN: 1664-3224 Impact factor: 7.561
Figure 3In vivo macrophage signatures predict survival in osteosarcoma cancer biopsy transcriptomes. Survival data for human osteosarcoma cancer biopsies (GSE21257) were analyzed for the impact of M1(=LPS+) and classically activated (LPS+IFN-γ) (A) and M2(=LPS−) and alternatively activated (IL-4) (B) gene expression signatures in the tumor biopsy transcriptome. Kaplan–Meier curves were plotted using ProggeneV2, divided by the median of the mean expression of a tumor-specific gene list (in boxes). Hazard ratio (HR, cox proportional hazard analysis) and significance (log rank P-value) are shown. Red, green curves indicate high, low expression of the respective signature genes. The two vertical black lines indicates 3 and 5 years, respectively.