Literature DB >> 32159532

The elucidation of phospholipid bilayer-small molecule interactions using a combination of phospholipid nanodiscs and solution state NMR techniques.

Georgina Townshend1, Gary S Thompson, Lisa J White, Jennifer R Hiscock, Jose L Ortega-Roldan.   

Abstract

Quantifying phospholipid bilayer-small molecule interactions is vital to the development of new drug candidates and/or medicinal therapies. However, obtaining these data remains problematic. Herein, we detail a phospholipid nanodisc assay which enables the elucidation of these interactions using conventional solution state NMR spectroscopy techniques.

Entities:  

Year:  2020        PMID： 32159532     DOI： 10.1039/c9cc09948d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  7 in total

1.  Supramolecular self-associating amphiphiles (SSAs) as enhancers of antimicrobial agents towards Escherichia coli (E. coli).

Authors:  Jessica E Boles; Rebecca J Ellaby; Helena J Shepherd; Jennifer R Hiscock
Journal:  RSC Adv       Date:  2021-03-03       Impact factor: 4.036

2.  Towards the Prediction of Antimicrobial Efficacy for Hydrogen Bonded, Self-Associating Amphiphiles.

Authors:  Nyasha Allen; Lisa J White; Jessica E Boles; George T Williams; Dominique F Chu; Rebecca J Ellaby; Helena J Shepherd; Kendrick K L Ng; Laura R Blackholly; Ben Wilson; Daniel P Mulvihill; Jennifer R Hiscock
Journal:  ChemMedChem       Date:  2020-10-16       Impact factor: 3.466

Review 3.  The phospholipid membrane compositions of bacterial cells, cancer cell lines and biological samples from cancer patients.

Authors:  Kira L F Hilton; Chandni Manwani; Jessica E Boles; Lisa J White; Sena Ozturk; Michelle D Garrett; Jennifer R Hiscock
Journal:  Chem Sci       Date:  2021-09-28       Impact factor: 9.825

4.  Supramolecular self-associating amphiphiles (SSAs) as nanoscale enhancers of cisplatin anticancer activity.

Authors:  Nova O Dora; Edith Blackburn; Jessica E Boles; George T Williams; Lisa J White; Scarlett E G Turner; J Daniel Hothersall; Trevor Askwith; Jack A Doolan; Daniel P Mulvihill; Michelle D Garrett; Jennifer R Hiscock
Journal:  RSC Adv       Date:  2021-04-15       Impact factor: 4.036

5.  Establishing the selective phospholipid membrane coordination, permeation and lysis properties for a series of 'druggable' supramolecular self-associating antimicrobial amphiphiles.

Authors:  Jessica E Boles; Charlotte Bennett; Jennifer Baker; Kira L F Hilton; Hiral A Kotak; Ewan R Clark; Yifan Long; Lisa J White; Hin Yuk Lai; Charlotte K Hind; J Mark Sutton; Michelle D Garrett; Anne Cheasty; Jose L Ortega-Roldan; Mark Charles; Cally J E Haynes; Jennifer R Hiscock
Journal:  Chem Sci       Date:  2022-08-10       Impact factor: 9.969

6.  Towards the Application of Supramolecular Self-Associating Amphiphiles as Next-Generation Delivery Vehicles.

Authors:  Lisa J White; Jessica E Boles; Kira L F Hilton; Rebecca J Ellaby; Jennifer R Hiscock
Journal:  Molecules       Date:  2020-09-09       Impact factor: 4.411

7.  Squaramide-Based Self-Associating Amphiphiles for Anion Recognition.

Authors:  Lokesh K Kumawat; Conor Wynne; Emanuele Cappello; Peter Fisher; Luke E Brennan; Alessandro Strofaldi; Jennifer J McManus; Chris S Hawes; Katrina A Jolliffe; Thorfinnur Gunnlaugsson; Robert B P Elmes
Journal:  Chempluschem       Date:  2021-08       Impact factor: 2.863
  7 in total

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