Transvenous Transseptal Concurrent Inoue Balloon Mitral and Aortic Valvuloplasty in an Octogenarian With Severe Aortic and Mitral Stenosis.

An octogenarian was admitted because of severe aortic stenosis (AS) and mitral stenosis. He declined surgical double-valve replacement and underwent intracardiac echocardiography-guided transseptal puncture and concurrent Inoue (Toray, Tokyo, Japan) balloon aortic valvuloplasty (BAV) and balloon mitral valvuloplasty (BMV). Nine months later, he had worsening pulmonary edema and received a second session of Inoue BAV and BMV. Our case shows that concurrent transseptal Inoue BAV and BMV can treat severe AS and mitral stenosis with adequate safety and efficacy. However, the durability is limited in elderly persons with calcified AS. The procedure should be reserved for patients who refuse surgery.

Combined severe aortic stenosis (AS) and mitral stenosis (MS) is double obstruction of blood flow at the left side of the heart, resulting in a lower cardiac output and pulmonary edema. In the coexistence of MS and AS, the severity of valve stenosis can be underestimated because of the low-flow and low-gradient situation. The standard management should be combined surgical aortic and mitral valve replacement. Other options include transcatheter aortic valve implantation (TAVI) plus percutaneous transseptal Inoue (Toray, Tokyo, Japan) balloon mitral valvuloplasty (BMV), concurrent transvenous transseptal Inoue balloon aortic valvuloplasty (BAV) and BMV, or transvenous transseptal BMV and retrograde transarterial BAV. In decision making, fiscal constraint remained an issue for TAVI because many public insurances did not reimburse for expensive devices.

We present an octogenarian with severe MS and AS who strongly declined surgical double-valve replacement. Within 1.5 years, he underwent 2 rescue sessions of intracardiac echocardiography (ICE)-guided transseptal and concurrent transvenous transseptal BAV and BMV for relieving pulmonary edema.

Case

An 82-year-old man was referred to our hospital (Taichung Veterans General Hospital) because of combined severe AS and MS with worsening dyspnea and pulmonary edema. The baseline echocardiographic data revealed transaortic valve peak/mean pressure gradients of 71/33 mm Hg, transmitral valve peak/mean pressure gradients of 19/8 mm Hg, and normal left ventricular ejection fraction of 55%. Hemodynamic data derived from cardiac catheterization showed a low cardiac output of 2.9 L/min (by the Fick method) and systolic pulmonary arterial pressure of 81 mm Hg, which indicated a combined obstructive effect of 2 severe valvular stenoses. He strongly declined surgical double valve replacement after a full discussion with the cardiac surgeons. The heart team rejected him as a candidate for TAVI because of combined severe MS. The patient had pulmonary edema and persistent heart failure signs, so we decided to perform transvenous transseptal concurrent BAV and BMV on December 30, 2013. We followed the protocol proposed by Abdou et al., except that we modified the procedure using ICE to guide the transseptal puncture (Fig. 1). In brief, the transatrial septal puncture was performed using a Brockenbrough needle and Mullins sheath with ICE guidance (Figure 1, Figure 2A). After transseptal puncture, the Mullins sheath was advanced from the right atrium (RA) to the left atrium (LA) (Fig. 2B) and positioned in the left ventricle (LV) (Fig. 2C). A Swan-Ganz balloon catheter was then advanced through the Mullins sheath to reach the LV and looped around the LV apex (Fig. 2C). A curved long wire (260 cm long, 0.025 inch in diameter, J-curve) was placed inside the Swan-Ganz catheter, looping up from the LV apex to the outflow tract, crossing the aortic valve first to the ascending aorta and then to the descending aorta. The curved long wire was snared at the left external iliac artery (Fig. 2D) before being externalized outside the left femoral artery sheath, forming a stable right femoral vein, RA, LA, LV, aorta, left femoral artery wire loop, and rail. The Swan-Ganz catheter and Mullins sheath were then removed, leaving the guide wire with a wide loop in the LV. The stretched Inoue balloon catheter was advanced over the guide wire to the LA (Fig. 2E). The Inoue balloon catheter was de-stretched, and a stretch metal tube was withdrawn to leave its tip approximately 2 cm into the LA beyond atrial septum (Fig. 2F). The Inoue balloon was tracked via the 0.025-inch wire loop from the right femoral vein, RA, LA, and LV to the ascending aorta and was pulled back, saddled at the aortic annulus level, and inflated to 20 mm (BAV) (Fig. 2G). Afterward, the BMV was done with the same Inoue balloon inflated up to 24 mm at the mitral annulus level (Fig. 2H). The transaortic valve mean pressure gradient decreased from 35 to 10 mm Hg, and the transmitral valve mean pressure gradient decreased from 15 to 5 mm Hg after intervention. Pulmonary edema resolved in the following days, and the patient was discharged uneventfully. Nine months after the first intervention, he developed pulmonary edema and was again admitted to our hospital (Taichung Veterans General Hospital). The echocardiogram showed moderately severe AS with a transaortic valve mean pressure gradient of 23 mm Hg and moderately severe MS with transmitral valve mean pressure gradient of 8 mm Hg. A repeated session of concurrent transvenous/transseptal Inoue BAV and BMV was performed successfully in September 2014. Pulmonary edema improved, and a few days later the patient was discharged. In January 2015, TAVI was scheduled, but the patient had tarry stool and coffee-grounds vomitus on the admission day and the plan was postponed. In February 2015, the patient fell accidentally, resulting in a bad head trauma with severe subdural hematoma. He died after neurosurgery.

Figure 1

Intracardiac echocardiogram image showing tenting of transseptal needle on fossa ovalis. Arrow: transseptal needle. LA, left atrium; RA, right atrium.

Figure 2

Step-by-step procedure sequences in transvenous transseptal concurrent Inoue (Toray, Tokyo, Japan) balloon mitral and aortic valvuloplasty. (A) The transseptal needle dilator (arrow) advances across the atrial septum into the left atrium (LA). Arrowhead: Intracardiac echocardiogram catheter. (B) After the transseptal procedure, the Mullins sheath was advanced to the LA. (C) The Swan-Ganz balloon catheter (arrow) was advanced to left ventricle (LV) through the Mullins sheath (arrowhead). With a slightly deep seating of the Mullins sheath in the LV, the balloon catheter was advanced to form an upward loop in the LV, directed toward the outflow tract and across the aortic valve to the ascending aorta. (D) A 260-cm, 0.025-inch wire was advanced inside the Swan-Ganz catheter from the ascending aorta to the abdominal aorta and then the iliac artery. The wire was externalized with a snare (arrow) at the left iliac artery for anchoring outside the left femoral arterial sheath. (E) The Swan-Ganz catheter and Mullins sheath were removed, leaving the guide wire with a loop in the LV. The stretched Inoue balloon catheter was advanced over the guide wire to the LA (arrow). (F) The Inoue balloon catheter was de-stretched, and the stretch metal tube was withdrawn to leave its tip (arrow) approximately 2 cm into the LA beyond the atrial septum. Thereafter, catheter manipulation was supported by the guide wire, anchored at both distal and proximal ends, as well as by stretch metal tube fixed across atrial septum (arrow). (G) The Inoue balloon was advanced to the ascending aorta, partially inflated, retracted to the saddle at the aortic annulus, and inflated up to 20 mm. Arrow: The transvenous/transseptal wire (from the right femoral vein, RA, LA, LV, and ascending/descending aorta externalized at the left femoral artery) (H). The Inoue balloon was retracted to the mitral annulus level and inflated to 24 mm. Arrow: Intracardiac echocardiogram catheter.

Discussion

Antegrade transseptal concurrent Inoue balloon concurrent BAV and BMV has been proposed as an effective alternative treatment for subjects with combined AS and MS since 1998. The method has been modified in various versions over the past 20 years. The differences among those changes include the following: BMV first or BAV first, leaving the transvenous/transseptal wire in the descending aorta, or fixing it with a snare or snaring it and externalization outside the left femoral artery. We have modification of the procedure in adopting an ICE guidance in transseptal puncture, which could help visualize the atrial septum clearly and improve its safety. Other than this modification, we closely followed the protocol proposed by Abdou et al, with BAV first strategy, and snaring the transvenous/transseptal wire and externalizing it outside the left femoral artery to achieve better wire support and stability.

Previous reports showed a 0.5% systemic embolic event rate for transvenous BMV and a 1% stroke rate for retrograde transarterial BAV. There were also reports of a 1% event rate of aggravated severe mitral regurgitation requiring surgery after transvenous BMV and a 0.5% event rate of increasing 2 grades of aortic regurgitation (vs baseline) after transarterial BAV. The small-scale (N = 14) study for transvenous, transseptal concurrent Inoue BAV/BMV reported no systemic thromboembolism or worsening regurgitation. To decrease thromboembolic complications, we suggested intraprocedure unfractionated heparin to maintain the activated clotting time over 250 seconds and postprocedure oral warfarin use for subjects with rheumatic heart disease and atrial fibrillation. Compared with transarterial retrograde BAV, transvenous/transseptal BAV has less entry site vascular injury and less LV wiring injury. Inoue balloon, compared with conventional balloons, also confers better aortic annulus sealing and dilatation effect for aortic valve stenosis.,

Regarding the efficacy and durability of transseptal concurrent BMV and BAV, past case series or registries usually reported better efficacy and durability in younger subjects with rheumatic AS and MS. Older adults with calcified degenerative AS had less favorable efficacy and treatment durability. For case selection, the concurrent transvenous transseptal BAV and BMV should be performed in younger subjects with rheumatic heart disease–related AS and MS with commissure fusion but without severe leaflet or annulus calcification and without preexisting more than moderate regurgitations. Our case is an elderly man aged 82 years with rheumatic MS but calcified AS, and thus had restenosis and clinical worsening 9 months after the first intervention.

Conclusion

Our case showed that transvenous/transseptal concurrent Inoue BAV and BMV may be safe and effective in relieving pulmonary edema and heart failure in subjects with combined severe AS and MS. However, the durability is limited in elderly patients with calcified aortic valves. The procedure should be reserved only for those who are unable to tolerate standard surgical double-valve replacement.

Transvenous/transseptal concurrent Inoue BAV and BMV may be safe and effective in relieving heart failure in subjects with combined severe AS and MS.

The durability is limited in senile calcified AS.

Adding ICE guidance for transseptal procedure increases safety.

Funding Sources

The authors have no funding sources to declare.

Disclosures

The authors have no conflicts of interest to disclose.