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Literature DB >> 32158931

PSPC1: a contextual determinant of tumor progression.

Abstract

Protein-tyrosine kinase 6 (PTK6) sequestrated by its substrate paraspeckle component 1 (PSPC1) in nucleus is a tumor suppressor. PSPC1 functions as a contextual determinant of oncogenic subcellular translocations to synergize PSPC1/β-catenin and PTK6 tumorigenesis. Besides, PSPC1 C-terminal interacting domain (PSPC1-CT131), a dual inhibitor of PSPC1 and PTK6, suppresses cancer progression.

Entities: Disease Gene

Keywords: CSC; EMT; HCC; Oncogenic subcellular translocation; metastasis

Year: 2020 PMID： 32158931 PMCID： PMC7051164 DOI： 10.1080/23723556.2020.1721253

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

8 in total

1. Redefining Biology via Enzyme Engineering.

Authors: Mirna Kvajo
Journal: Cell Date: 2017-01-12 Impact factor: 41.582

2. PSPC1 mediates TGF-β1 autocrine signalling and Smad2/3 target switching to promote EMT, stemness and metastasis.

Authors: Hsi-Wen Yeh; En-Chi Hsu; Szu-Shuo Lee; Yaw-Dong Lang; Yuh-Charn Lin; Chieh-Yu Chang; Suz-Yi Lee; De-Leung Gu; Jou-Ho Shih; Chun-Ming Ho; Chian-Feng Chen; Chiung-Tong Chen; Pang-Hsien Tu; Ching-Feng Cheng; Ruey-Hwa Chen; Ruey-Bing Yang; Yuh-Shan Jou
Journal: Nat Cell Biol Date: 2018-03-28 Impact factor: 28.824

Review 3. A New Switch for TGFβ in Cancer.

Authors: Hsi-Wen Yeh; Szu-Shuo Lee; Chieh-Yu Chang; Yaw-Dong Lang; Yuh-Shan Jou
Journal: Cancer Res Date: 2019-07-12 Impact factor: 12.701

Review 4. Cell motility in cancer invasion and metastasis: insights from simple model organisms.

Authors: Christina H Stuelten; Carole A Parent; Denise J Montell
Journal: Nat Rev Cancer Date: 2018-03-16 Impact factor: 60.716

Review 5. Molecular Pathways: Anticancer Activity by Inhibition of Nucleocytoplasmic Shuttling.

Authors: Fabio Conforti; Yisong Wang; Jose A Rodriguez; Anna Teresa Alberobello; Yu-Wen Zhang; Giuseppe Giaccone
Journal: Clin Cancer Res Date: 2015-08-31 Impact factor: 12.531

Review 6. EMT Transition States during Tumor Progression and Metastasis.

Authors: Ievgenia Pastushenko; Cédric Blanpain
Journal: Trends Cell Biol Date: 2018-12-26 Impact factor: 20.808

7. An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells.

Authors: Anna Bafico; Guizhong Liu; Luba Goldin; Violaine Harris; Stuart A Aaronson
Journal: Cancer Cell Date: 2004-11 Impact factor: 31.743

8. PSPC1 potentiates TGF-β-dependent metastatic dissemination.

Authors: Hsi-Wen Yeh; Yuh-Shan Jou
Journal: Mol Cell Oncol Date: 2018-08-01

8 in total

5 in total

PSPC1: a contextual determinant of tumor progression.

1. Redefining Biology via Enzyme Engineering.

2. PSPC1 mediates TGF-β1 autocrine signalling and Smad2/3 target switching to promote EMT, stemness and metastasis.

Review 3. A New Switch for TGFβ in Cancer.

Review 4. Cell motility in cancer invasion and metastasis: insights from simple model organisms.

Review 5. Molecular Pathways: Anticancer Activity by Inhibition of Nucleocytoplasmic Shuttling.

Review 6. EMT Transition States during Tumor Progression and Metastasis.

7. An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells.

8. PSPC1 potentiates TGF-β-dependent metastatic dissemination.

Review 1. Targeting protein tyrosine kinase 6 in cancer.

2. PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility.

3. The Prognosis Value of PSPC1 Expression in Nasopharyngeal Cancer.

Review 4. RNA-Binding Proteins in the Regulation of Adipogenesis and Adipose Function.

Review 5. PSPC1 is a new contextual determinant of aberrant subcellular translocation of oncogenes in tumor progression.