Literature DB >> 32158928

How autophagy is tied to inflammation and cancer.

Qing Zhu1, Ruifang Wang1, Dali Nemecio1, Chengyu Liang1.   

Abstract

It is not completely understood how autophagy is tied to inflammation and age-related cancer predisposition. Here, we used a mouse model with inducible expression of a cancer-derived frameshift mutation in UV radiation resistance associated (UVRAG) to demonstrate that intervention with autophagy suppressor could exacerbate inflammation and promote age-related spontaneous cancers.
© 2020 Taylor & Francis Group, LLC.

Entities:  

Keywords:  UVRAG; autophagy; centrosome; inflammation; tumorigenesis; β-catenin

Year:  2020        PMID： 32158928      PMCID： PMC7051155          DOI： 10.1080/23723556.2020.1717908

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  9 in total

1.  Toll-like receptors control autophagy.

Authors:  Mónica A Delgado; Rasha A Elmaoued; Alexander S Davis; George Kyei; Vojo Deretic
Journal:  EMBO J       Date:  2008-03-13       Impact factor: 11.598

2.  Vacuolar Trafficking Protein VPS38 Is Dispensable for Autophagy.

Authors:  Han Nim Lee; Xavier Zarza; Jeong Hun Kim; Min Ji Yoon; Sang-Hoon Kim; Jae-Hoon Lee; Nadine Paris; Teun Munnik; Marisa S Otegui; Taijoon Chung
Journal:  Plant Physiol       Date:  2017-11-28       Impact factor: 8.340

3.  A dual role for UVRAG in maintaining chromosomal stability independent of autophagy.

Authors:  Zhen Zhao; Soohwan Oh; Dapeng Li; Duojiao Ni; Sara Dolatshahi Pirooz; Joo-Hyung Lee; Shunhua Yang; June-Yong Lee; Irene Ghozalli; Vincenzo Costanzo; Jeremy M Stark; Chengyu Liang
Journal:  Dev Cell       Date:  2012-04-26       Impact factor: 12.270

Review 4.  Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment.

Authors:  Zhenyu Zhong; Elsa Sanchez-Lopez; Michael Karin
Journal:  Cell       Date:  2016-07-14       Impact factor: 41.582

5.  Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae.

Authors:  A Kihara; T Noda; N Ishihara; Y Ohsumi
Journal:  J Cell Biol       Date:  2001-02-05       Impact factor: 10.539

6.  PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex.

Authors:  Shanshan He; Duojiao Ni; Binyun Ma; Joo-Hyung Lee; Tian Zhang; Irene Ghozalli; Sara Dolatshahi Pirooz; Zhen Zhao; Nagakumar Bharatham; Baihong Li; Soohwan Oh; Wen-Hwa Lee; Yoshinori Takahashi; Hong-Gang Wang; Arlet Minassian; Pinghui Feng; Vojo Deretic; Rainer Pepperkok; Mitsuo Tagaya; Ho Sup Yoon; Chengyu Liang
Journal:  Nat Cell Biol       Date:  2013-09-22       Impact factor: 28.824

7.  Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase.

Authors:  Yongfei Yang; Shanshan He; Qiaoxiu Wang; Fan Li; Mi-Jeong Kwak; Sally Chen; Douglas O'Connell; Tian Zhang; Sara Dolatshahi Pirooz; Yong Heui Jeon; Nyam-Osor Chimge; Baruch Frenkel; Younho Choi; Grace M Aldrovandi; Byung-Ha Oh; Zengqiang Yuan; Chengyu Liang
Journal:  Mol Cell       Date:  2016-05-19       Impact factor: 17.970

8.  Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers.

Authors:  Shanshan He; Zhen Zhao; Yongfei Yang; Douglas O'Connell; Xiaowei Zhang; Soohwan Oh; Binyun Ma; Joo-Hyung Lee; Tian Zhang; Bino Varghese; Janae Yip; Sara Dolatshahi Pirooz; Ming Li; Yong Zhang; Guo-Min Li; Sue Ellen Martin; Keigo Machida; Chengyu Liang
Journal:  Nat Commun       Date:  2015-08-03       Impact factor: 14.919

9.  A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice.

Authors:  Christine Quach; Ying Song; Hongrui Guo; Shun Li; Hadi Maazi; Marshall Fung; Nathaniel Sands; Douglas O'Connell; Sara Restrepo-Vassalli; Billy Chai; Dali Nemecio; Vasu Punj; Omid Akbari; Gregory E Idos; Shannon M Mumenthaler; Nancy Wu; Sue Ellen Martin; Ashley Hagiya; James Hicks; Hengmin Cui; Chengyu Liang
Journal:  Nat Commun       Date:  2019-12-12       Impact factor: 14.919
  9 in total
  1 in total

1.  Narciclasine attenuates sepsis-induced myocardial injury by modulating autophagy.

Authors:  Rong Tang; Liu Jia; Yunlong Li; Junbo Zheng; Pingping Qi
Journal:  Aging (Albany NY)       Date:  2021-05-25       Impact factor: 5.682
  1 in total

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