Literature DB >> 32158924

From tumorigenesis to cell death: the aneuploidy paradox.

Sylvie Rodrigues-Ferreira1,2,3,4, Clara Nahmias1,2,3.   

Abstract

Aneuploidy, an abnormal chromosome number, is a hallmark of cancer. We recently showed that depletion of microtubule-associated protein ATIP3 (AT2 receptor-interacting protein 3) induces aneuploidy and sensitizes breast cancer cells to taxanes. Combining taxane treatment with ATIP3 depletion cooperates to reach a detrimental level of aneuploidy.
© 2019 Taylor & Francis Group, LLC.

Entities:  

Keywords:  ATIP3; Breast cancer; MTUS1; centrosome amplification; chromosome instability; multipolar spindle; predictive biomarker; taxanes

Year:  2020        PMID： 32158924      PMCID： PMC7051165          DOI： 10.1080/23723556.2019.1709390

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  7 in total

1.  Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells.

Authors:  Begoña Cánovas; Ana Igea; Alessandro A Sartori; Roger R Gomis; Tanya T Paull; Michitaka Isoda; Héctor Pérez-Montoyo; Violeta Serra; Eva González-Suárez; Travis H Stracker; Angel R Nebreda
Journal:  Cancer Cell       Date:  2018-05-24       Impact factor: 31.743

Review 2.  Short- and long-term effects of chromosome mis-segregation and aneuploidy.

Authors:  Stefano Santaguida; Angelika Amon
Journal:  Nat Rev Mol Cell Biol       Date:  2015-08       Impact factor: 94.444

3.  8p22 MTUS1 gene product ATIP3 is a novel anti-mitotic protein underexpressed in invasive breast carcinoma of poor prognosis.

Authors:  Sylvie Rodrigues-Ferreira; Anne Di Tommaso; Ariane Dimitrov; Sylvie Cazaubon; Nadège Gruel; Hélène Colasson; André Nicolas; Nathalie Chaverot; Vincent Molinié; Fabien Reyal; Brigitte Sigal-Zafrani; Benoit Terris; Olivier Delattre; François Radvanyi; Franck Perez; Anne Vincent-Salomon; Clara Nahmias
Journal:  PLoS One       Date:  2009-10-01       Impact factor: 3.240

4.  ATIP3, a novel prognostic marker of breast cancer patient survival, limits cancer cell migration and slows metastatic progression by regulating microtubule dynamics.

Authors:  Angie Molina; Lauriane Velot; Lydia Ghouinem; Mohamed Abdelkarim; Benjamin Pierre Bouchet; Anny-Claude Luissint; Imène Bouhlel; Marina Morel; Elène Sapharikas; Anne Di Tommaso; Stéphane Honoré; Diane Braguer; Nadège Gruel; Anne Vincent-Salomon; Olivier Delattre; Brigitte Sigal-Zafrani; Fabrice André; Benoit Terris; Anna Akhmanova; Mélanie Di Benedetto; Clara Nahmias; Sylvie Rodrigues-Ferreira
Journal:  Cancer Res       Date:  2013-02-08       Impact factor: 12.701

5.  Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors.

Authors:  Alain D Silk; Lauren M Zasadil; Andrew J Holland; Benjamin Vitre; Don W Cleveland; Beth A Weaver
Journal:  Proc Natl Acad Sci U S A       Date:  2013-10-16       Impact factor: 11.205

6.  Mps1 inhibitors synergise with low doses of taxanes in promoting tumour cell death by enhancement of errors in cell division.

Authors:  Ana Rita R Maia; Simon Linder; Ji-Ying Song; Chantal Vaarting; Ute Boon; Colin E J Pritchard; Arno Velds; Ivo J Huijbers; Olaf van Tellingen; Jos Jonkers; René H Medema
Journal:  Br J Cancer       Date:  2018-05-08       Impact factor: 7.640

7.  Mild replication stress causes chromosome mis-segregation via premature centriole disengagement.

Authors:  Therese Wilhelm; Anna-Maria Olziersky; Daniela Harry; Filipe De Sousa; Helène Vassal; Anja Eskat; Patrick Meraldi
Journal:  Nat Commun       Date:  2019-08-08       Impact factor: 14.919
  7 in total
  1 in total

Review 1.  Microtubule-Associated Protein ATIP3, an Emerging Target for Personalized Medicine in Breast Cancer.

Authors:  Maria M Haykal; Sylvie Rodrigues-Ferreira; Clara Nahmias
Journal:  Cells       Date:  2021-05-01       Impact factor: 6.600
  1 in total

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