Literature DB >> 32158921

Adenylosuccinate lyase hydroxylation contributes to triple negative breast cancer via the activation of cMYC.

Giada Zurlo1, Qing Zhang1.   

Abstract

Hydroxylation is a post-translational modification affecting protein stability, activity or interactome. We identified adenylosuccinate lyase (ADSL) as a novel hydroxylation substrate in triple negative breast cancer. Hydroxylation affects ADSL enzymatic activity and, therefore, adenosine levels. Adenosine, in turn, favors the translation of cMYC, triggering its oncogenic downstream cascade.
© 2020 Taylor & Francis Group, LLC.

Entities:  

Keywords:  ADSL; adenosine; cMYC; hydroxylation; triple negative breast cancer

Year:  2020        PMID： 32158921      PMCID： PMC7051151          DOI： 10.1080/23723556.2019.1707045

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  8 in total

1.  The MYC mRNA 3'-UTR couples RNA polymerase II function to glutamine and ribonucleotide levels.

Authors:  Francesca R Dejure; Nadine Royla; Steffi Herold; Jacqueline Kalb; Susanne Walz; Carsten P Ade; Guido Mastrobuoni; Jens T Vanselow; Andreas Schlosser; Elmar Wolf; Stefan Kempa; Martin Eilers
Journal:  EMBO J       Date:  2017-04-13       Impact factor: 11.598

Review 2.  Posttranscriptional gene regulation by long noncoding RNA.

Authors:  Je-Hyun Yoon; Kotb Abdelmohsen; Myriam Gorospe
Journal:  J Mol Biol       Date:  2012-11-23       Impact factor: 5.469

3.  Human adenylosuccinate lyase (ADSL), cloning and characterization of full-length cDNA and its isoform, gene structure and molecular basis for ADSL deficiency in six patients.

Authors:  S Kmoch; H Hartmannová; B Stibůrková; J Krijt; M Zikánová; I Sebesta
Journal:  Hum Mol Genet       Date:  2000-06-12       Impact factor: 6.150

Review 4.  MYC, Metabolism, and Cancer.

Authors:  Zachary E Stine; Zandra E Walton; Brian J Altman; Annie L Hsieh; Chi V Dang
Journal:  Cancer Discov       Date:  2015-09-17       Impact factor: 39.397

Review 5.  New Insights into Protein Hydroxylation and Its Important Role in Human Diseases.

Authors:  Giada Zurlo; Jianping Guo; Mamoru Takada; Wenyi Wei; Qing Zhang
Journal:  Biochim Biophys Acta       Date:  2016-09-20

Review 6.  Platelets: the holy grail in cancer blood biomarker research?

Authors:  Siamack Sabrkhany; Marijke J E Kuijpers; Arjan W Griffioen; Mirjam G A Oude Egbrink
Journal:  Angiogenesis       Date:  2019-02       Impact factor: 9.596

7.  EglN2 contributes to triple negative breast tumorigenesis by functioning as a substrate for the FBW7 tumor suppressor.

Authors:  Mamoru Takada; Ming Zhuang; Hiroyuki Inuzuka; Jing Zhang; Giada Zurlo; Jinfang Zhang; Qing Zhang
Journal:  Oncotarget       Date:  2017-01-24

8.  Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.

Authors:  Matthew E Cockman; James D Webb; Holger B Kramer; Benedikt M Kessler; Peter J Ratcliffe
Journal:  Mol Cell Proteomics       Date:  2008-10-20       Impact factor: 5.911
  8 in total
  1 in total

1.  Exploring the potential biomarkers for prognosis of glioblastoma via weighted gene co-expression network analysis.

Authors:  Mengyuan Zhang; Zhike Zhou; Zhouyang Liu; Fangxi Liu; Chuansheng Zhao
Journal:  PeerJ       Date:  2022-01-18       Impact factor: 2.984
  1 in total

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