Literature DB >> 32158920

Histone deacetylases facilitate the accurate repair of broken forks.

Belén Gómez-González1, Pedro Ortega1, Andrés Aguilera1.   

Abstract

We have recently uncovered that loss of the yeast histone deacetylases Rpd3 (Reduced Potassium Dependency 3) and Hda1 (Histone DeAcetylase 3) affects the cohesion between sister chromatids thus impairing repair of DNA damage at replication forks and enhancing genetic instability. Here we discuss the possible implications of our findings given that histone deacetylases are a promising chemotherapeutic target often used in combination with DNA damaging agents.
© 2020 Taylor & Francis Group, LLC.

Entities:  

Keywords:  Histone deacetylases; cohesion; double-strand break repair; histone deacetylase inhibitors; sister-chromatid recombination

Year:  2020        PMID： 32158920      PMCID： PMC7051162          DOI： 10.1080/23723556.2019.1705731

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Suppression of RAD21 gene expression decreases cell growth and enhances cytotoxicity of etoposide and bleomycin in human breast cancer cells.

Authors:  Josephine M Atienza; Richard B Roth; Caridad Rosette; Kevin J Smylie; Stefan Kammerer; Joachim Rehbock; Jonas Ekblom; Mikhail F Denissenko
Journal:  Mol Cancer Ther       Date:  2005-03       Impact factor: 6.261

2.  Double-strand breaks arising by replication through a nick are repaired by cohesin-dependent sister-chromatid exchange.

Authors:  Felipe Cortés-Ledesma; Andrés Aguilera
Journal:  EMBO Rep       Date:  2006-08-04       Impact factor: 8.807

Review 3.  S-phase and DNA damage activated establishment of sister chromatid cohesion--importance for DNA repair.

Authors:  Camilla Sjögren; Lena Ström
Journal:  Exp Cell Res       Date:  2010-01-04       Impact factor: 3.905

4.  Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks.

Authors:  Patrick Ryan Potts; Matthew H Porteus; Hongtao Yu
Journal:  EMBO J       Date:  2006-06-29       Impact factor: 11.598

5.  Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair.

Authors:  J-H Lee; M L Choy; L Ngo; S S Foster; Paul A Marks
Journal:  Proc Natl Acad Sci U S A       Date:  2010-08-02       Impact factor: 11.205

6.  Human THO-Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability.

Authors:  Irene Salas-Armenteros; Carmen Pérez-Calero; Aleix Bayona-Feliu; Emanuela Tumini; Rosa Luna; Andrés Aguilera
Journal:  EMBO J       Date:  2017-10-26       Impact factor: 11.598

Review 7.  Repair of endogenous DNA damage.

Authors:  T Lindahl; D E Barnes
Journal:  Cold Spring Harb Symp Quant Biol       Date:  2000

Review 8.  Oncogenic Viruses and Breast Cancer: Mouse Mammary Tumor Virus (MMTV), Bovine Leukemia Virus (BLV), Human Papilloma Virus (HPV), and Epstein-Barr Virus (EBV).

Authors:  James S Lawson; Brian Salmons; Wendy K Glenn
Journal:  Front Oncol       Date:  2018-01-22       Impact factor: 6.244

9.  Rpd3L Contributes to the DNA Damage Sensitivity of Saccharomyces cerevisiae Checkpoint Mutants.

Authors:  Belén Gómez-González; Harshil Patel; Anne Early; John F X Diffley
Journal:  Genetics       Date:  2018-12-17       Impact factor: 4.562

10.  Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion.

Authors:  Pedro Ortega; Belén Gómez-González; Andrés Aguilera
Journal:  Nat Commun       Date:  2019-11-15       Impact factor: 14.919
  10 in total
  1 in total

1.  In Vitro Assessment of the Genotoxic Hazard of Novel Hydroxamic Acid- and Benzamide-Type Histone Deacetylase Inhibitors (HDACi).

Authors:  Annabelle Friedrich; Ann-Sophie Assmann; Lena Schumacher; Jana V Stuijvenberg; Matthias U Kassack; Wolfgang A Schulz; Wynand P Roos; Finn K Hansen; Marc Pflieger; Thomas Kurz; Gerhard Fritz
Journal:  Int J Mol Sci       Date:  2020-07-03       Impact factor: 5.923
  1 in total

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