Literature DB >> 32158912

New control of the senescence barrier in breast cancer.

Tânia D F Costa1, Staffan Strömblad1.   

Abstract

Normal cells exposed to cancer-causing events respond by triggering cellular senescence, a stress response which halts cell proliferation and constitutes a protective anti-cancer barrier. We have uncovered a previously unknown signaling pathway implicating p21-activated kinase 4 (PAK4) in the control of senescence in breast cancer, via the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) subunit RELB and the CCAAT-enhancer-binding protein beta (C/EBPβ).
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

Entities:  

Keywords:  CEBPB; Cellular senescence; PAK4; RELB; p21-activated kinase

Year:  2020        PMID： 32158912      PMCID： PMC7051141          DOI： 10.1080/23723556.2019.1684129

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Unmasking senescence: context-dependent effects of SASP in cancer.

Authors:  Douglas V Faget; Qihao Ren; Sheila A Stewart
Journal:  Nat Rev Cancer       Date:  2019-06-24       Impact factor: 60.716

2.  Glioblastomas require integrin αvβ3/PAK4 signaling to escape senescence.

Authors:  Aleksandra Franovic; Kathryn C Elliott; Laetitia Seguin; M Fernanda Camargo; Sara M Weis; David A Cheresh
Journal:  Cancer Res       Date:  2015-08-21       Impact factor: 12.701

Review 3.  Cellular senescence: from physiology to pathology.

Authors:  Daniel Muñoz-Espín; Manuel Serrano
Journal:  Nat Rev Mol Cell Biol       Date:  2014-07       Impact factor: 94.444

Review 4.  PAK signalling during the development and progression of cancer.

Authors:  Maria Radu; Galina Semenova; Rachelle Kosoff; Jonathan Chernoff
Journal:  Nat Rev Cancer       Date:  2014-01       Impact factor: 60.716

Review 5.  P21 activated kinase signaling in cancer.

Authors:  Chetan K Rane; Audrey Minden
Journal:  Semin Cancer Biol       Date:  2018-01-09       Impact factor: 15.707

6.  Pak4 induces premature senescence via a pathway requiring p16INK4/p19ARF and mitogen-activated protein kinase signaling.

Authors:  Marta S Cammarano; Tanya Nekrasova; Beatrice Noel; Audrey Minden
Journal:  Mol Cell Biol       Date:  2005-11       Impact factor: 4.272

Review 7.  Pharmacological targeting of RAS: Recent success with direct inhibitors.

Authors:  John P O'Bryan
Journal:  Pharmacol Res       Date:  2018-10-23       Impact factor: 7.658

8.  Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.

Authors:  Freddie Bray; Jacques Ferlay; Isabelle Soerjomataram; Rebecca L Siegel; Lindsey A Torre; Ahmedin Jemal
Journal:  CA Cancer J Clin       Date:  2018-09-12       Impact factor: 508.702

9.  Deciphering the role of nuclear factor-κB in cellular senescence.

Authors:  Simon Vaughan; Parmjit S Jat
Journal:  Aging (Albany NY)       Date:  2011-10       Impact factor: 5.682

10.  Double-slit photoelectron interference in strong-field ionization of the neon dimer.

Authors:  Maksim Kunitski; Nicolas Eicke; Pia Huber; Jonas Köhler; Stefan Zeller; Jörg Voigtsberger; Nikolai Schlott; Kevin Henrichs; Hendrik Sann; Florian Trinter; Lothar Ph H Schmidt; Anton Kalinin; Markus S Schöffler; Till Jahnke; Manfred Lein; Reinhard Dörner
Journal:  Nat Commun       Date:  2019-01-02       Impact factor: 14.919
  10 in total
  1 in total

1.  A Study on the Effect of the Substituent against PAK4 Inhibition Using In Silico Methods.

Authors:  Hye Ree Yoon; Chong Chul Chai; Cheol Hee Kim; Nam Sook Kang
Journal:  Int J Mol Sci       Date:  2022-03-19       Impact factor: 5.923
  1 in total

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